Document Server@UHasselt >
Research publications >
Please use this identifier to cite or link to this item:
|Title: ||Placental Mitochondrial DNA Content and Particulate Air Pollution During in Utero Life|
|Other Titles: ||Mitochondrial DNA6content and air pollution in utero|
|Authors: ||Janssen, Bram|
Nawrot, Tim S.
|Issue Date: ||2012|
|Citation: ||ENVIRONMENTAL HEALTH PERSPECTIVES, 120(9), p. 1346-1352|
|Abstract: ||BACKGROUND: Studies emphasize the importance of particulate matter (PM) in the
formation of reactive oxygen species and inflammation. We hypothesized that these
processes can influence mitochondrial function of the placenta and fetus.
OBJECTIVES: We investigated the influence of PM10 exposure during pregnancy on the
mitochondrial DNA6content (mtDNA content) of the placenta and umbilical cord blood.
METHODS: DNA was extracted from placental tissue (n = 174) and umbilical cord
leukocytes (n = 176). Relative mtDNA copy numbers (i.e. mtDNA content) were determined
by real6time PCR. Multiple regression models were used to link mtDNA content and in utero
exposure to PM10 over various time windows during pregnancy.
RESULTS: In multivariate6adjusted analysis, a 106Cg/m³ increase in PM10 exposure during
the last month of pregnancy was associated with a 16.1% decrease (95% CI: 625.2, 66.0%, p =
0.003) in placental mtDNA content. The corresponding effect6size for average PM10 exposure
during the third trimester was 17.4% (95% CI: 631.8, 60.1%, p = 0.05). Furthermore, we
found that each doubling in residential distance to major roads was associated with an
increase in placental mtDNA content of 4.0% (95% CI: 0.4, 7.8%, p = 0.03).
No association was found between cord blood mtDNA content and PM10 exposure.
CONCLUSIONS: Prenatal PM10 exposure was associated with placental mitochondrial
alterations, which may both reflect and intensify oxidative stress production. The potential
health consequences of decreased placental mtDNA content in early life must be further
|ISI #: ||000308786900036|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2013|
|Appears in Collections: ||Research publications|
Files in This Item:
|N/A||532.23 kB||Adobe PDF|
|Published version ||356.47 kB||Adobe PDF|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.