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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13730

Title: Physiological and molecular characterisation of cadmium stress in Schmidtea mediterranea
Authors: Plusquin, Michelle
Stevens, An-Sofie
Van Belleghem, Frank
Degheselle, Olivier
Van Roten, Andromeda
Vroonen, Jessica
Blust, Ronny
Cuypers, Ann
Artois, Tom
Smeets, Karen
Issue Date: 2012
Publisher: U B C PRESS
Abstract: The planarian Schmidtea mediterranea is a well-studied model organism for developmental research, because of its stem cell system. This characteristic also provides a unique opportunity to study stress management and the effect of stress on stem cells. In this study, we characterised the stress signature at different levels of biological organization. The carcinogenic metal cadmium was used as a model chemical stressor. We focused on stem cell activity and its interaction with other known stress parameters. Here, we have found that S. mediterranea is able to cope with high internal levels of cadmium. At endpoints such as size and mobility, cadmium-related stress effects were detected but all of these responses were transient. Correspondingly, cadmium exposure led to an elevated mitotic activity of the neoblasts, at the same time points when the other responses disappeared. At the molecular level, we observed redox-related responses that can be linked with both repair as well as proliferation mechanisms. Together, our results suggest that these animals have a high plasticity. The induction of stem cell activity may underlie this 'restoring' effect, although a carcinogenic outcome after longer exposure times cannot be excluded.
Notes: [Plusquin, Michelle] Hasselt Univ, Ctr Environm Sci, BE-3590 Diepenbeek, Belgium. [Van Belleghem, Frank] Open Univ Nederland, Sch Sci, Heerlen, Netherlands. [Blust, Ronny] Univ Antwerp, Antwerp, Belgium.
URI: http://hdl.handle.net/1942/13730
DOI: 10.1387/ijdb.113485mp
ISI #: 000303844500019
ISSN: 0214-6282
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

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