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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13722

Title: Development of multichannel quartz crystal microbalances for MIP-based biosensing
Authors: Croux, Dieter
Weustenraed, Ans
Pobedinskas, Paulius
Horemans, Frederik
Dilien, Hanne
Haenen, Ken
Cleij, Thomas J.
Wagner, Patrick
Thoelen, Ronald
De Ceuninck, Ward
Issue Date: 2012
Publisher: WILEY-V C H VERLAG GMBH
Citation: PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 209 (5), p. 892-899
Abstract: Molecularly imprinted polymers (MIPs) offer a huge potential in the development of cheap small-scale disposable biomimetic sensors. They are suited for a wide variety of biological targets and are compatible with many different measurement techniques such as gravimetric sensing and impedance spectroscopy. One potential sensor platform for MIP-based biosensors is the quartz crystal microbalance (QCM). A 4-channel MIP/non-imprinted polymer (NIP) coated QCM biosensor array was developed on a single piece of quartz crystal. To study cross-channel frequency coupling of the resonance modes, a simulation of crystal designs using finite element analysis (FEA) modeling was created. Based on these simulations and using reactive ion etching (RIE) to create mesa-like structures on the crystal surface, crosstalk can be severely reduced. The improved functionality compared to the traditional QCMs was demonstrated by employing these mesa-type multichannel QCM (MQCM) crystals as an L-nicotine biosensor platform. (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Notes: [Croux, Dieter; Weustenraed, Ans; Pobedinskas, Paulius; Horemans, Frederik; Dilien, Hanne; Haenen, Ken; Cleij, Thomas; Wagner, Patrick; De Ceuninck, Ward] Hasselt Univ, IMO, B-3590 Diepenbeek, Belgium. [Haenen, Ken; Wagner, Patrick; De Ceuninck, Ward] IMOMEC, IMEC VZW, B-3590 Diepenbeek, Belgium. [Thoelen, Ronald] XIOS Univ Coll, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/13722
DOI: 10.1002/pssa.201100715
ISI #: 000303386900016
ISSN: 1862-6300
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

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