www.uhasselt.be
DSpace

Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13720

Title: Detection of L-nicotine with dissipation mode quartz crystal microbalance using molecular imprinted polymers
Authors: ALENUS, Jan
GALAR, Pavel
ETHIRAJAN, Anitha
HOREMANS, Frederik
WEUSTENRAED, Ans
CLEIJ, Thomas
WAGNER, Patrick
Issue Date: 2012
Publisher: WILEY-V C H VERLAG GMBH
Citation: PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 209 (5), p. 905-910
Abstract: Synthetic materials with imprinted nanocavities can act as highly selective tailor-made artificial receptors. Implementing these materials in a piezoelectric sensing device can offer fast and straightforward detection together with high sensitivity. L-nicotine, a major addictive substance in cigarettes is used as target molecule. The synthetic receptors for L-nicotine are made via the molecular imprinting technique. The target molecule is added to a monomer mixture containing initiator and this mixture is polymerized with heat. Subsequently, microparticles are obtained by crushing the bulk molecular imprinted polymers (MIPs), which are then immobilized on thin films of polyvinyl chloride. Using Quartz crystal microbalance, L-nicotine could be detected in the submicromolar range and the selectivity of the sensors was verified by reference measurements with L-cotinine. The effectiveness of the sensor was also tested for different aqueous fluids at different pH. It was found that MIPs bind 4.03 times more L-nicotine than non-imprinted polymer in water and 1.99 times more in 0.1 x phosphate buffer saline at pH 9. (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Notes: [Alenus, Jan; Ethirajan, Anitha; Horemans, Frederik; Weustenraed, Ans; Cleij, Thomas J.; Wagner, Patrick] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Galar, Pavel] Charles Univ Prague, Fac Math & Phys, CR-12116 Prague 2, Czech Republic. [Wagner, Patrick] IMEC Div IMOMEC, B-3590 Diepenbeek, Belgium. patrick.wagner@uhasselt.be
URI: http://hdl.handle.net/1942/13720
DOI: 10.1002/pssa.201100768
ISI #: 000303386900018
ISSN: 1862-6300
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
published version279.84 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.