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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13716

Title: Discussion Contribution to 091037PR4 (Ghosh, Taylor, and Sargent)
Authors: Molenberghs, Geert
Issue Date: 2012
Publisher: WILEY-BLACKWELL
Citation: BIOMETRICS, 68 (1), p. 233-235
Abstract: There has been great recent interest in the medical and statistical literature in the assessment and validation of surrogate endpoints as proxies for clinical endpoints in medical studies. More recently, authors have focused on using metaanalytical methods for quantification of surrogacy. In this article, we extend existing procedures for analysis based on the accelerated failure time model to this setting. An advantage of this approach relative to proportional hazards model is that is allows for analysis in the semicompeting risks setting, where we model the region where the surrogate endpoint occurs before the true endpoint. Several estimation methods and attendant inferential procedures are presented. In addition, between- and within-trial methods for evaluating surrogacy are developed; a novel principal components procedure is developed for quantifying trial-level surrogacy. The methods are illustrated by application to data from several studies in colorectal cancer.
Notes: [Molenberghs, Geert] Univ Hasselt, I BioStat, Diepenbeek, Belgium. [Molenberghs, Geert] Katholieke Univ Leuven, I BioStat, Louvain, Belgium.
URI: http://hdl.handle.net/1942/13716
DOI: 10.1111/j.1541-0420.2011.01634.x
ISI #: 000301924400030
ISSN: 0006-341X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

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