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|Title: ||Insights From a Cardiac Resynchronization Optimization Clinic as Part of a Heart Failure Disease Management Program|
|Authors: ||Mullens, Wilfried|
Grimm, Richard A.
Starling, Randall C.
Wilkoff, Bruce L.
Tang, W. H. Wilson
|Issue Date: ||2009|
|Citation: ||JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53 (9), p. 765-773|
|Abstract: ||Objectives Our aim was to determine the feasibility and value of a protocol-driven approach to patients with cardiac resynchronization therapy (CRT) who did not exhibit a positive response long after implant.
Background Up to one-third of patients with advanced heart failure do not exhibit a positive response to CRT.
Methods A total of 75 consecutive ambulatory patients with persistent advanced heart failure symptoms and/or adverse reverse remodeling and CRT implanted >6 months underwent a comprehensive protocol-driven evaluation to determine the potential reasons for a suboptimal response. Recommendations were made to maximize the potential of CRT, and adverse events were documented.
Results All patients ( mean left ventricular [LV] ejection fraction 23 +/- 9%, LV end-diastolic volume 275 +/- 127 ml) underwent evaluation. Eighty-eight percent of patients had significantly better echocardiographic indexes of LV filling and LV ejection with optimal setting of their CRT compared with a temporary VVI back-up setting. Most patients had identifiable reasons for suboptimal response, including inadequate device settings (47%), suboptimal medical treatment (32%), arrhythmias ( 32%), inappropriate lead position (21%), or lack of baseline dyssynchrony ( 9%). Multidisciplinary recommendations led to changes in device settings and/or other therapy modifications in 74% of patients and were associated with fewer adverse events (13% vs. 50%, odds ratio: 0.2 [95% confidence interval: 0.07 to 0.56], p = 0.002) compared with those in which no recommendation could be made.
Conclusions Routine protocol-driven approach to evaluate ambulatory CRT patients who did not exhibit a positive response is feasible, and changes in device settings and/or other therapies after multidisciplinary evaluation may be associated with fewer adverse events.|
|ISI #: ||000263667200006|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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