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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13181

Title: Effect of time of day on walking capacity and self-reported fatigue in persons with multiple sclerosis: a multi-center trial
Authors: Feys, Peter
Gijbels, Domien
Romberg, Anders
Santoyo, Carme
Gebara, Benoit
Maertens-de-Noordhout, Benoit
Knuts, Kathy
Bethoux, Francois
de Groot, Vincent
Vaney, Claude
Dalgas, Ulrik
Issue Date: 2012
Citation: Multiple Sclerosis Journal, 18(3), p.351-357
Abstract: Background: Many persons with multiple sclerosis (PwMS) report increased fatigue in the afternoon and evening compared with the morning. It is commonly accepted that physical capacity also decreases as time of day progresses, potentially influencing the outcomes of testing. Objective: The objective of this article was to determine whether self-reported fatigue level and walking capacity are influenced by time of day in PwMS. Methods: A total of 102 PwMS from 8 centers in 5 countries, with a diverse level of ambulatory dysfunction (Expanded Disability Status Scale [EDSS] <6.5), participated. Patients performed walking capacity tests and reported fatigue level at three different time points (morning, noon, afternoon) during 1 day. Walking capacity was measured with the 6-Minute Walk Test (6MWT) and the 10-m walk test performed at usual and fastest speed. Self-reported fatigue was measured by the Rochester Fatigue Diary (RFD). Subgroups with mild (EDSS 1.5–4.0, n=53) and moderate (EDSS 4.5–6.5, n=49) ambulatory dysfunction were formed, as changes during the day were hypothesized to depend on disability status. Results: Subgroups had different degree of ambulatory dysfunction (p < 0.001) but reported similar fatigue levels. Although RFD scores were affected by time of day with significant differences between morning and noon/afternoon (p < 0.0001), no changes in walking capacity were found in any subgroup. Additional analyses on subgroups distinguished by diurnal change in self-reported fatigue failed to reveal analogous changes in walking capacity. Conclusions: Testing of walking capacity is unaffected by time of day, despite changes in subjective fatigue.
URI: http://hdl.handle.net/1942/13181
DOI: 10.1177/1352458511419881
ISI #: 000300928700014
ISSN: 1352-4585
Category: A1
Type: Journal Contribution
Validation: ecoom, 2013
Appears in Collections: Research publications

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