Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/13003

Title: Decreased placental mitochondrial DNA-content in response to air pollution during in utero life
Authors: Janssen, Bram
Pieters, Nicky
Munters, Elke
Smeets, Karen
Cuypers, Ann
Penders, Joris
Vangronsveld, Jaco
Gyselaers, Wilfried
Nawrot, Tim
Issue Date: 2011
Abstract: Recent studies have emphasized the importance of PM, and its associated metal components, in the formation of reactive oxygen species (ROS) and inflammation. Mitochondria are the major intracellular sources and primary targets of ROS. Mitochondrial DNA (mtDNA) is particularly vulnerable to ROS-induced damage, resulting in a higher mutation rate that impacts mitochondrial function. Given its multiple essential roles in metabolic pathways, mitochondrial dysfunction (i.e. change in mtDNA-content) is important in fetal development. In utero exposure to environmental factors may influence mitochondrial function which may comprise a mechanism of earlier onset of multifactorial disease such as cardiovascular disease in later life1.
URI: http://hdl.handle.net/1942/13003
Category: C2
Type: Conference Material
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
N/A257.67 kBUnknown

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.