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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12921

Title: European Surveillance of Antimicrobial Consumption (ESAC): outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe (1997-2009)
Authors: Coenen, Samuel
Adriaenssens, Niels
Versporten, Ann
Muller, Arno
Minalu, Girma
Faes, Christel
Vankerckhoven, Vanessa
Aerts, Marc
Hens, Niel
Molenberghs, Geert
Goossens, Herman
Issue Date: 2011
Publisher: OXFORD UNIV PRESS
Citation: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 66, p. VI57-VI70
Abstract: Background: Data on more than a decade of outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in Europe were collected from 33 countries as part of the European Surveillance of Antimicrobial Consumption (ESAC) project, funded by the European Centre for Disease Prevention and Control (ECDC). Methods: For the period 1997-2009, data on outpatient use of systemic tetracyclines, sulphonamides and trimethoprim, and other antibacterials aggregated at the level of the active substance were collected and expressed in defined daily doses (DDD; WHO, version 2011) per 1000 inhabitants per day (DID). Using the Anatomical Therapeutic Chemical (ATC) classification, trends in the use of tetracyclines (J01A), sulphonamides and trimethoprim (J01E) and other antibacterials (J01X) over time, seasonal variation and composition of use were analysed. Results: In 2009, the variations in outpatient use of systemic tetracyclines, sulphonamides and trimethoprim, and other antibacterials between countries, and also in the composition of use over time, were huge. For tetracyclines a significant and for sulphonamides and trimethoprim a non-significant decrease in use was observed between 1997 and 2009 in Europe. The seasonal variation in their use significantly decreased over time. For the other antibacterials, no significant changes in the volume of use or its seasonal variation were seen. Conclusions: As for all other major antibiotic subgroups, a striking variation in use and composition of use between countries in Europe was observed for outpatient use of tetracyclines, sulphonamides and trimethoprim, and other antibacterials. In combination with the decreasing use, especially of recommended substances, this represents an opportunity not only to reduce antibiotic use but also to improve its quality.
Notes: [Coenen, Samuel; Adriaenssens, Niels; Versporten, Ann; Muller, Arno; Vankerckhoven, Vanessa; Goossens, Herman] Univ Antwerp, Lab Med Microbiol, Vaccine & Infect Dis Inst VAXINFECTIO, B-2020 Antwerp, Belgium. [Coenen, Samuel; Adriaenssens, Niels] Univ Antwerp, Ctr Gen Practice, Vaccine & Infect Dis Inst VAXINFECTIO, B-2020 Antwerp, Belgium. [Minalu, Girma; Faes, Christel; Aerts, Marc; Hens, Niel; Molenberghs, Geert] Univ Hasselt, Interuniv Inst Biostat & Stat Bioinformat I BIOST, Hasselt, Belgium. [Hens, Niel] Univ Antwerp, CHERMID, Vaccine & Infect Dis Inst VAXINFECTIO, B-2020 Antwerp, Belgium. [Molenberghs, Geert] Catholic Univ Louvain, Interuniv Inst Biostat & Stat Bioinformat I BIOST, B-3000 Louvain, Belgium.
URI: http://hdl.handle.net/1942/12921
DOI: 10.1093/jac/dkr458
ISI #: 000297228400007
ISSN: 0305-7453
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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