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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12827

Title: The Early Intertwining of the Heart and the Kidney Through an Impaired Natriuretic Response to Acute Volume Expansion
Authors: MULLENS, Wilfried
Tang, W. H. Wilson
Issue Date: 2011
Publisher: ELSEVIER SCIENCE INC
Citation: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(20), p. 2104-2105
Abstract: An estimated 20 million Americans may have heart failure without overt symptoms (stage B and early stage C), yet this syndrome remains poorly understood, and therapeutic options are largely limited to lifestyle and risk factor modifications. Although therapy with neurohormonal blockers should be considered for these patients, unless contraindicated, this recommendation is predominantly extrapolated from studies with systolic heart failure patients having minimal signs and symptoms. Therapies for isolated diastolic dysfunction are lacking, even though nearly 50% of heart failure is attributed to impaired diastolic rather than impaired systolic heart function. Understanding the pathophysiology of these pre-clinical stages of the disease is crucial, as treatment success is often considered the relief or prevention of systemic (venous) congestion.
Notes: [Mullens, W] Ziekenhuis Oost Limburg, Dept Cardiovasc Med, B-3600 Genk, Belgium. [Mullens, W] Transnat Univ Limburg, Sch Life Sci, Hasselt, Belgium. [Tang, WHW] Cleveland Clin, Dept Cardiovasc Med, Inst Heart & Vasc, Cleveland, OH 44106 USA. wilfried.mullens@zol.be
URI: http://hdl.handle.net/1942/12827
DOI: 10.1016/j.jacc.2011.05.064
ISI #: 000296603700008
ISSN: 0735-1097
Category: A2
Type: Journal Contribution
Appears in Collections: Research publications

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