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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12807

Title: Decreased placental mitochondrial DNA-content in response to air pollution during in utero life
Authors: Janssen, Bram
Advisors: NAWROT, Tim
Issue Date: 2011
Publisher: tUL Diepenbeek
Abstract: Ambient particulate matter is of great concern to human health. In this cross-sectional study, we investigated the influence of PM10 exposure during pregnancy on the mtDNA-content, an established marker of mitochondrial damage and dysfunction. We hypothesized that mtDNA-content changed during pregnancy in response to PM10 exposure and may underlie susceptibility to mitochondrial dysfunction. Our findings indicate a potential window for susceptibility by trimester exposure that may adversely affect mitochondrial function and possibly foetal outcome. Placental mtDNA-content is associated with distance to major road, a surrogate for traffic-related air pollution.
Notes: master in de biomedische wetenschappen-milieu en gezondheid
URI: http://hdl.handle.net/1942/12807
Category: T2
Type: Theses and Dissertations
Appears in Collections: Master theses

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