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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12799

Title: Migration of microglia in the embryonic neocortex
Authors: Smolders, Sophie
Advisors: RIGO, Jean-Michel
Issue Date: 2011
Publisher: tUL Diepenbeek
Abstract: Microglia, the brain macrophages, are suggested to implement key functions during development. In order to do so, they migrate extensively from their entry points to their final locations. However, the mechanisms for microglial migration during mammalian brain development are unknown. Therefore, the goals of this project were to elucidate the migratory behavior of microglia and to determine the presence of adhesion molecules, which could allow interaction with radial cells during murine cortical development. Based on immunohistochemical stainings and live imaging of acute brain slices (of CX3CR1 +/eGFP mice embryos), we suggest that microglia do not migrate according to a specific pattern in the developing neocortex. However, they show that during migration, microglia can adhere to radial cells through molecular interaction with laminin and fibronectin. Instead of following the entire course of the radial cells, microglia could make successive jumps between pillars of radial fibers.
Notes: master in de biomedische wetenschappen-klinische moleculaire wetenschappen
URI: http://hdl.handle.net/1942/12799
Category: T2
Type: Theses and Dissertations
Appears in Collections: Master theses

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