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Title: GABA(A) Receptor and Glycine Receptor Activation by Paracrine/Autocrine Release of Endogenous Agonists: More Than a Simple Communication Pathway
Authors: Le-Corronc, Herve
RIGO, Jean-Michel
Branchereau, Pascal
Legendre, Pascal
Issue Date: 2011
Citation: MOLECULAR NEUROBIOLOGY, 44(1). p. 28-52
Abstract: It is a common and widely accepted assumption that glycine and GABA are the main inhibitory transmitters in the central nervous system (CNS). But, in the past 20 years, several studies have clearly demonstrated that these amino acids can also be excitatory in the immature central nervous system. In addition, it is now established that both GABA receptors (GABARs) and glycine receptors (GlyRs) can be located extrasynaptically and can be activated by paracrine release of endogenous agonists, such as GABA, glycine, and taurine. Recently, non-synaptic release of GABA, glycine, and taurine gained further attention with increasing evidence suggesting a developmental role of these neurotransmitters in neuronal network formation before and during synaptogenesis. This review summarizes recent knowledge about the non-synaptic activation of GABA(A)Rs and GlyRs, both in developing and adult CNS. We first present studies that reveal the functional specialization of both non-synaptic GABA(A)Rs and GlyRs and we discuss the neuronal versus non-neuronal origin of the paracrine release of GABA(A)R and GlyR agonists. We then discuss the proposed non-synaptic release mechanisms and/or pathways for GABA, glycine, and taurine. Finally, we summarize recent data about the various roles of non-synaptic GABAergic and glycinergic systems during the development of neuronal networks and in the adult.
Notes: [Branchereau, P] Univ Bordeaux, INCIA, F-33405 Talence, France. [Branchereau, P] CNRS, UMR 5287, F-33405 Talence, France. [Le-Corronc, H; Legendre, P] Univ Paris 06, INSERM, U952, CNRS,UMR 7224, F-75005 Paris, Ile De France, France. [Le-Corronc, H] Univ Angers, Angers, France. [Rigo, JM] Hasselt Univ, BIOMED Cell Physiol, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/12360
DOI: 10.1007/s12035-011-8185-1
ISI #: 000295282500004
ISSN: 0893-7648
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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