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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12260

Title: Vertebral fractures in women aged 50 years and older with clinical risk factors for fractures in primary care
Authors: van den Berg, Martha
Verdijk, Noortje A.
van den Bergh, Joop P. W.
Talboom-Kamp, Esther P. W. A.
Leusink, Geraline L.
Pop, Victor J. M.
Issue Date: 2011
Citation: MATURITAS, 70(1). p. 74-79
Abstract: Background: The identification of vertebral fractures (VFs) is important for decisions on fracture prevention. Vertebral fracture assessment (VFA) was shown to be a patient-friendly and valid method for detecting undiagnosed VFs in (Dutch) women. However, this has only been investigated in women seeking care at secondary or tertiary institutions. Objective: To investigate the prevalence of previously undiagnosed VFs in women in Dutch primary care using VFA. Study design: A total of 566 Dutch women aged 50 years and older (mean age, 69 years; SD = 8.4) with clinical risk factors (CRFs) for fractures volunteered for dual-energy X-ray absorptiometry (DXA) measurement and VFA. VFs were defined semi-quantitatively using Genant's method. Results: One CRF was present in each of 130 women, 274 had two, and 162 women had more than two CRFs. In 120(21%) of the women, previously unknown osteoporosis (T-score <= -2.5 SD) was diagnosed, and in 174(31%), a previously undiagnosed moderate or severe VF was found. No osteoporosis was found in 130 (75%) of the women with a VF. Based on the outcome of DXA, 21% of the women were eligible for treatment, while the combination of DXA and VFA resulted in a total of 250 (44%) women requiring treatment. Conclusions: The percentage of previously unknown VFs diagnosed by VFA in women aged 50 years and older with one or more CRFs for fractures in primary care is high. When only using BMD measurements, only half the women eligible for treatment would actually receive this. We recommend performing VFA in all women aged 50 years and older who are referred for DXA based on Dutch case finding criteria. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Notes: [van den Berg, M; Pop, VJM] Tilburg Univ, CoRPS Ctr Res Psychol Somat Dis, NL-5000 LE Tilburg, Netherlands [Verdijk, NA; Talboom-Kamp, EPWA] Diagnostiek U, NL-5600 CK Eindhoven, Netherlands [van den Bergh, JPW] VieCuri Med Ctr Noord Limburg, Dept Internal Med, NL-5900 BX Venlo, Netherlands [van den Bergh, JPW] Maastricht Univ Nutrim, Fac Hlth Med & Life Sci, Dept Internal Med, NL-6200 MD Maastricht, Netherlands [Geusens, PP] Maastricht Univ Caphri, Fac Hlth Med & Life Sci, Dept Internal Med, NL-6200 MD Maastricht, Netherlands [Geusens, PP] Univ Hasselt, Biomed Res Ctr, Diepenbeek, Belgium [Leusink, GL] Stichting Zuidwester, NL-3240 AA Middelharnis, Netherlands m.caers@pozob.nl; noortje.verdijk@diagnostiekvooru.nl; jvdbergh@hetnet.nl; piet.geusens@scarlet.be; esther.talboom@diagnostiekvooru.nl; g.leusink@zuidwester.org; v.j.m.pop@uvt.nl
URI: http://hdl.handle.net/1942/12260
DOI: 10.1016/j.maturitas.2011.06.006
ISI #: 000294940900014
ISSN: 0378-5122
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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