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|Title: ||Hepatic venous wave protraction time is longer in late than in early pregnancy|
|Authors: ||Tomsin, Kathleen|
|Issue Date: ||2010|
|Citation: ||The life sciences summit - Biomedica, Aachen, Germany, 17-18/03/2010|
Venous pulse waves, as obtained by Duplex Ultrasonography, are a reflection of cardiac right atrial function. The time-interval between cardiac electrocardiographic (ECG) signals and venous Doppler waves is the so-called Venous Wave Protraction Time (VWPT).
To evaluate Hepatic Vein (HV) VWPT at different stages of gestation.
Cross-sectional study in 4 groups of 10 women at gestations (1) 10-14 weeks, (2) 18-23 weeks, (3) 28-33 weeks and (4) ≥ 37 weeks. Three consecutive venous Doppler waves were recorded at the craniocaudal midportion of the liver from each of the three main branches of HV, simultaneously with an ECG. The time-interval between the ECG P-wave and corresponding A-deflection of venous Doppler waves was measured, without or with correction for gestation-induced changing heart rate (PA and PA/RR respectively). For each group, means and SD were calculated and compared statistically using conventional F-tests for linear mixed-effects models (SAS procedure MIXED).
PA and PA/RR were significantly larger at term than in the first trimester [337±74 versus 220±47 msec, p=0.0008 and 0.48±0.15 versus 0.29±0.09, p=0.0009 respectively]. When groups at early-, mid- and late gestation were compared, VWPT increased gradually with gestational age.
VWPT is significantly longer in late than in early pregnancy. This observation probably relates to maternal cardiovascular adaptation mechanisms, i.e. venous tone. Our study illustrates that VWPT may be a new parameter to study venous hemodynamics during pregnancy.|
|Type: ||Conference Material|
|Appears in Collections: ||Research publications|
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