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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12040

Title: Revealing age-specific past and future unrelated costs of pneumococcal infections by flexible generalized estimating equations
Authors: CREEMERS, An
AERTS, Marc
HENS, Niel
SHKEDY, Ziv
De Smet, Frank
Beutels, Philippe
Issue Date: 2011
Publisher: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
Citation: JOURNAL OF APPLIED STATISTICS, 38 (8). p. 1533-1547
Abstract: We aimed to study the excess health-care expenditures for persons with a known positive isolate of Streptococcus pneumoniae. The data set was compiled by linking the database of the largest Belgian Sickness Fund with data obtained from laboratories reporting pneumococcal isolates. We analyzed the age-specific per-patient cumulative costs over time, using generalized estimating equations (GEEs). The mean structure was described by fractional polynomials. The quasi-likelihood under the independence model criterion was used to compare different correlation structures. We show for all age groups that the health-care costs incurred by diagnosed pneumococcal patients are significantly larger than those incurred by undiagnosed matched persons. This is not only the case at the time of diagnosis but also long before and after the time of diagnosis. These findings can be informative for the current debate on unrelated costs in health economic evaluation, and GEEs could be used to estimate these costs for other diseases. Finally, these results can be used to inform policy on the expected budget impact of preventing pneumococcal infections.
Notes: [Creemers, An; Aerts, Marc; Hens, Niel; Shkedy, Ziv] Hasselt Univ, Interuniv Inst Biostat, Diepenbeek, Belgium. [Creemers, An; Aerts, Marc; Hens, Niel; Shkedy, Ziv] Catholic Univ Leuven, Louvain, Belgium. [Hens, Niel; Beutels, Philippe] Univ Antwerp, Ctr Evaluat Vaccinat, Ctr Hlth Econ Res & Modeling Infect Dis, B-2020 Antwerp, Belgium. [Hens, Niel; Beutels, Philippe] Univ Antwerp, Vaccine & Infect Dis Inst, B-2020 Antwerp, Belgium. [De Smet, Frank] Natl Alliance Christian Mutual, Med Direct, Brussels, Belgium. an.creemers@uhasselt.be
URI: http://hdl.handle.net/1942/12040
DOI: 10.1080/02664763.2010.515302
ISI #: 000291464400001
ISSN: 0266-4763
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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