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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/12021

Title: Mesenchymal stem cells or cardiac progenitors for cardiac repair? A comparative study
Authors: KONINCKX, Remco
Daniels, Annick
WINDMOLDERS, Severina
Carlotti, Francoise
Mees, Urbain
STEELS, Paul
RUMMENS, Jean-Luc
HENDRIKX, Marc
Hensen, Karen
Issue Date: 2011
Publisher: BIRKHAUSER VERLAG AG
Citation: CELLULAR AND MOLECULAR LIFE SCIENCES, 68 (12). p. 2141-2156
Abstract: In the past, clinical trials transplanting bone marrow-derived mononuclear cells reported a limited improvement in cardiac function. Therefore, the search for stem cells leading to more successful stem cell therapies continues. Good candidates are the so-called cardiac stem cells (CSCs). To date, there is no clear evidence to show if these cells are intrinsic stem cells from the heart or mobilized cells from bone marrow. In this study we performed a comparative study between human mesenchymal stem cells (hMSCs), purified c-kit(+) CSCs, and cardiosphere-derived cells (CDCs). Our results showed that hMSCs can be discriminated from CSCs by their differentiation capacity towards adipocytes and osteocytes and the expression of CD140b. On the other hand, cardiac progenitors display a greater cardiomyogenic differentiation capacity. Despite a different isolation protocol, no distinction could be made between c-kit(+) CSCs and CDCs, indicating that they probably derive from the same precursor or even are the same cells.
Notes: [Koninckx, Remco; Daniels, Annick; Windmolders, Severina; Rummens, Jean-Luc; Hensen, Karen] Jessa Hosp, Lab Expt Hematol, B-3500 Hasselt, Belgium. [Koninckx, Remco; Windmolders, Severina; Steels, Paul; Rummens, Jean-Luc; Hendrikx, Marc] Hasselt Univ, Biomed Res Inst, Physiol Lab, Fac Med, B-3590 Diepenbeek, Belgium. [Koninckx, Remco; Windmolders, Severina; Steels, Paul; Rummens, Jean-Luc; Hendrikx, Marc] Hasselt Univ, Biomed Res Inst, Sch Life Sci, B-3590 Diepenbeek, Belgium. [Koninckx, Remco; Windmolders, Severina; Steels, Paul; Hendrikx, Marc] Transnat Univ Limburg, B-3590 Diepenbeek, Belgium. [Carlotti, Francoise] Leiden Univ, Med Ctr, Dept Mol Cell Biol, NL-2300 RC Leiden, Netherlands. [Mees, Urbain; Hendrikx, Marc] Jessa Hosp, Dept Cardiothorac Surg, B-3500 Hasselt, Belgium. karen.hensen@jessazh.be
URI: http://hdl.handle.net/1942/12021
DOI: 10.1007/s00018-010-0560-y
ISI #: 000290960100011
ISSN: 1420-682X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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