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|Title: ||LATE VITAMIN K DEFICIENCY BLEEDING LEADING TO A DIAGNOSIS OF CYSTIC FIBROSIS: A CASE REPORT|
|Authors: ||Ngo, B.|
Van Pelt, K.
Van De Casseye, W.
|Issue Date: ||2011|
|Publisher: ||ACTA CLINICA BELGICA|
|Citation: ||ACTA CLINICA BELGICA, 66(2). p. 142-143|
|Abstract: ||Vitamin K deficiency bleeding (VKDB) in infants still occurs despite worldwide use of prophylaxis. Clinical manifestations can be dramatic with over 50% of patients presenting with intracranial haemorrhage and a mortality rate of 20% in late vitamin K deficiency bleeding. Special attention should be given to infants with a high risk profile (preterm, breast feeding, cholestasis, malabsorption). A tentative diagnosis can be made observing quick normalisation of some easy-to-perform haemostatic parameters (PT, aPTT) after administration of vitamin K. Nowadays, VKDB can still be the first clinical sign of diseases causing malabsorption of fat-soluble vitamins. In this case report, VKDB led to the diagnosis of cystic fibrosis, the most common fatal autosomal recessive disease among Caucasian people.|
|Notes: ||[Ngo, B.; Van Pelt, K.; Van De Casseye, W.; Penders, J.] Ziekenhuis Oost Limburg, Lab Clin Biol, Genk, Belgium. [Labarque, V] UZ Leuven, Dept Paediat Haematooncol, Leuven, Belgium. [Van De Casseye, W.] UZ Leuven, Dept Paediat, Leuven, Belgium. [Penders, J.] Hasselt Univ, Fac Med, Diepenbeek, Belgium.|
|ISI #: ||000290931300012|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2012|
|Appears in Collections: ||Research publications|
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