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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11880

Title: Exploring the Impact of Exposure to Primary Varicella in Children on Varicella-Zoster Virus Immunity of Parents
Authors: Ogunjimi, Benson
Smits, Evelien
HENS, Niel
Hens, Annick
Lenders, Kevin
Ieven, Margareta
Van Tendeloo, Viggo
Van Damme, Pierre
Beutels, Philippe
Issue Date: 2011
Citation: VIRAL IMMUNOLOGY, 24(2). p. 151-157
Abstract: Varicella-zoster virus (VZV) causes both primary varicella, and through reactivation of the virus, herpes zoster. It is hypothesized that VZV-immune adults may reduce the probability of developing herpes zoster through exposure to varicella. In this study we examine the existence of immunological boosting in VZV-immune adults after close contact with primary varicella. We followed-up 18 parents with household exposure to primary varicella for 1 y. Fifteen age-matched healthy and 20 older volunteers served as control groups. Cellular (IFN-gamma ELISPOT) and humoral responses were measured. Data analyses were performed by t-tests and linear mixed models. The young control group only showed higher cellular responses than the older control group and the exposed group 1 mo after exposure. The exposed group had a strong tendency toward higher cellular responses compared to the older control group, reaching significance 1 y post-exposure. The best fitting linear mixed model predicts a decline in cellular response of 50% between 1 wk and 1 mo post-exposure, followed by an increase to attain an 80% higher level at 1 y compared to the first week post-exposure. No significant results emerged based on the humoral response of the individual parents in the exposed group, despite a general tendency toward higher antibody concentrations in the exposed versus the control groups. No significant difference in humoral immunity was found between the control groups. One year after initial re-exposure to VZV, VZV-immune adults showed a rise in cellular response as assessed by IFN-g ELISPOT, and steady-state levels for the humoral response.
Notes: [Ogunjimi, Benson] Univ Antwerp, Fac Med, Vaccine & Infect Dis Inst, CHERMID, B-2610 Antwerp, Belgium. [Ogunjimi, Benson; Hens, Niel; Hens, Annick; Van Damme, Pierre; Beutels, Philippe] Univ Antwerp, Vaccine & Infect Dis Inst, CEV, B-2610 Antwerp, Belgium. [Smits, Evelien; Lenders, Kevin; Van Tendeloo, Viggo] Univ Antwerp, Vaccine & Infect Dis Inst, Lab Expt Hematol, B-2610 Antwerp, Belgium. [Ieven, Margareta] Univ Antwerp, Vaccine & Infect Dis Inst, Dept Microbiol, B-2610 Antwerp, Belgium. [Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Beutels, Philippe] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia.
URI: http://hdl.handle.net/1942/11880
DOI: 10.1089/vim.2010.0031
ISI #: 000288983000010
ISSN: 0882-8245
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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