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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11640

Title: Traffic Air Pollution and Oxidized LDL.
Authors: Jacobs, Lotte
Emmerechts, Jan
Hoylaerts, Marc
Mathieu, Chantal
Hoet, Peter
Nemery, Benoit
NAWROT, Tim
Issue Date: 2011
Publisher: PLOS
Citation: Plos One, 6(1). p. e16200-e16200
Abstract: Background: Epidemiologic studies indirectly suggest that air pollution accelerates atherosclerosis. We hypothesized that individual exposure to particulate matter (PM) derived from fossil fuel would correlate with plasma concentrations of oxidized low-density lipoprotein (LDL), taken as a marker of atherosclerosis. We tested this hypothesis in patients with diabetes, who are at high risk for atherosclerosis. Methodology/Principal Findings: In a cross-sectional study of non-smoking adult outpatients with diabetes we assessed individual chronic exposure to PM by measuring the area occupied by carbon in airway macrophages, collected by sputum induction and by determining the distance from the patient’s residence to a major road, through geocoding. These exposure indices were regressed against plasma concentrations of oxidized LDL, von Willebrand factor and plasminogen activator inhibitor 1 (PAI-1). We could assess the carbon load of airway macrophages in 79 subjects (58 percent). Each doubling in the distance of residence from major roads was associated with a 0.027 mm2 decrease (95% confidence interval (CI): 20.048 to 20.0051) in the carbon load of airway macrophages. Independently from other covariates, we found that each increase of 0.25 mm2 [interquartile range (IQR)] in carbon load was associated with an increase of 7.3 U/L (95% CI: 1.3 to 13.3) in plasma oxidized LDL. Each doubling in distance of residence from major roads was associated with a decrease of 22.9 U/L (95% CI: 25.2 to 20.72) in oxidized LDL. Neither the carbon load of macrophages nor the distance from residence to major roads, were associated with plasma von Willebrand factor or PAI-1. Conclusions: The observed positive association, in a susceptible group of the general population, between plasma oxidized LDL levels and either the carbon load of airway macrophages or the proximity of the subject’s residence to busy roads suggests a proatherogenic effect of traffic air pollution.
URI: http://hdl.handle.net/1942/11640
DOI: 10.1371/journal.pone.0016200
ISI #: 000286520600029
ISSN: 1932-6203
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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