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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11601

Title: Generalized pairwise comparisons of prioritized outcomes in the two-sample problem
Authors: BUYSE, Marc
Issue Date: 2010
Citation: STATISTICS IN MEDICINE, 29 (30). p. 3245-3257
Abstract: This paper extends the idea behind the U-statistic of the Wilcoxon-Mann-Whitney test to perform generalized pairwise comparisons between two groups of observations. The observations are outcomes captured by a single variable, possibly repeatedly measured, or by several variables of any type (e.g. discrete, continuous, time to event). When several outcomes are considered, they must be prioritized. We show that generalized pairwise comparisons extend well-known non-parametric tests, and illustrate their interest using data from two randomized clinical trials. We also show that they lead to a general measure of the difference between the groups called the 'proportion in favor of treatment', denoted Delta, which is related to traditional measures of treatment effect for a single variable. Copyright (C) 2010 John Wiley & Sons, Ltd.
Notes: [Buyse, Marc] Int Inst Drug Dev, B-1340 Louvain, Belgium. [Buyse, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BioSt, Hasselt, Belgium. marc.buyse@iddi.com
URI: http://hdl.handle.net/1942/11601
DOI: 10.1002/sim.3923
ISI #: 000285846300017
ISSN: 0277-6715
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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