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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11595

Title: Long-term outcome of thalamic deep brain stimulation in two patients with Tourette syndrome
Authors: Ackermans, Linda
Duits, Annelien
Temel, Yasin
Winogrodzka, Ania
Peeters, Frenk
BEULS, Emile
Visser-Vandewalle, Veerle
Issue Date: 2010
Abstract: Objective Thalamic deep brain stimulation for intractable Tourette Syndrome was introduced in 1999 by Vandewalle et al. In this follow-up study, the authors report on the long-term (6 and 10 years) outcome in terms of tic reduction, cognition, mood and side effects of medial thalamic deep brain stimulation in two previously described Tourette patients. Methods The authors compared the outcome of two patients at 6 and 10 years after surgery with their preoperative status and after 8 months and 5 years of treatment, respectively. Standardised video recordings were scored by three independent investigators. Both patients underwent (neuro) psychological assessment at all time points of follow-up. Results Tic improvement observed at 5 years in patient 1 (90.1%) was maintained at 10 years (92.6%). In patient 2, the tic improvement at 8 months (82%) was slightly decreased at 6 years (78%). During follow-up, case 1 revealed no changes in cognition, but case 2 showed a decrease in verbal fluency and learning which was in line with his subjective reports. Case 2 showed a slight decrease in depression, but overall psychopathology was still high at 6 years after surgery with an increase in anger and aggression together with difficulties in social adaptation. Besides temporary hardware-related complications, no distressing adverse effects were observed. Conclusion Bilateral thalamic stimulation may provide sustained tic benefit after at least 6 years, but to maximise overall outcome, attention is needed for postoperative psychosocial adaptation, already prior to surgery.
Notes: [Ackermans, Linda; Temel, Yasin; Beuls, Emile A. M.; Visser-Vandewalle, Veerle] Maastricht Univ, Med Ctr, Dept Neurosurg, Maastricht Inst Neuromodulat Dev, NL-6229 EV Maastricht, Netherlands. [Ackermans, Linda; Duits, Annelien; Temel, Yasin; Winogrodzka, Ania; Peeters, Frenk; Visser-Vandewalle, Veerle] Maastricht Univ, Sch Mental Hlth & Neurosci MHENS, Med Ctr, NL-6229 EV Maastricht, Netherlands. [Beuls, Emile A. M.] Univ Hasselt, Dept Basic Med Sci, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/11595
DOI: 10.1136/jnnp.2009.176859
ISI #: 000282176900046
ISSN: 0022-3050
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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