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|Title: ||THE METABOLIC SYNDROME AND CAROTID INTIMA-MEDIA THICKNESS IN RELATION TO THE PARATHYROID HORMONE TO 25-OH-D3 RATIO IN A GENERAL POPULATION|
|Authors: ||Richart, T.|
Struijker-Boudier, H. A.
Staessen, J. A.
|Issue Date: ||2010|
|Publisher: ||LIPPINCOTT WILLIAMS & WILKINS|
|Citation: ||JOURNAL OF HYPERTENSION, 28. p. E129-E129|
|Abstract: ||Objective: Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure and arterial calcification. We hypothesized that lower calcium intake as reflected by circulating PTH and 25-OH-D3 might be associated with the metabolic syndrome (MS) and arterial calcification. Design and method: In a random population sample (n = 542; 50.5% women;
mean age, 49.8 13.1 years), we measured MS prevalence (IDF and AHA criteria), PTH and 25-OH-D3, serum and 24-h urinary calcium, MS components,
carotid intima-media thickness (CIMT) and calcium intake from
dairy products. We assessed associations in multivariable-adjusted analyses,
using linear and logistic regressions.
Results: The prevalence of MS was 21.0% (IDF criteria) and 23.6% (AHA
criteria). MS prevalence, blood pressure, waist circumference, body mass
index, fasting blood glucose, insulin and triglycerides, and CIMT increased
(P<0.042) across quartiles of the PTH/25-OH-D3 ratio, whereas serum and
24-h urinary calcium decreased (P<0.029). Waist circumference and fasting
blood glucose decreased across quartiles of habitual calcium intake
(P<0.04). In models that included MS (IDF) and PTH/25-OH-D3, the
regression coefficients for PTH/25-OH-D3 ratio and MS were +51.3-m
(P = 0.013) and +18.9-m (P = 0.45), respectively. Multivariable adjusted
analyses were confirmatory. Conclusions: MS prevalence and CIMT were positively associated with PTH/25-OH-D3. CIMT was not associated with MS In the presence of
PTH/25-OH-D3. Assuming causal and reversible associations, a high dietary calcium intake might protect against arterial calcification and MS.|
|Notes: ||[Richart, T.; Thijs, L.; Yu, J.; Kuznetsova, T.; Staessen, J. A.] Studies Coordinating Ctr, Div Hypertens & Cardiovasc Rehabil, Dept Cardiovasc Dis, Leuven, Belgium. [Richart, T.; Staessen, J. A.] Maastricht Univ, Dept Epidemiol, Genet Epidemiol Unit, Maastricht, Netherlands. [Nawrot, T.] Univ Hasselt, Lab Biol & Geol, Dept Chem Biol & Geol, Hasselt, Belgium. [Segers, P.] Univ Ghent, Cardiovasc Mech & Biofluid Dynam Res Grp, IBiTech, B-9000 Ghent, Belgium. [Balkestein, J.; Struijker-Boudier, H. A.] Maastricht Univ, Dept Pharmacol, Maastricht, Netherlands.|
|ISI #: ||000283023402272|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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