www.uhasselt.be
DSpace

Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11593

Title: THE METABOLIC SYNDROME AND CAROTID INTIMA-MEDIA THICKNESS IN RELATION TO THE PARATHYROID HORMONE TO 25-OH-D3 RATIO IN A GENERAL POPULATION
Authors: Richart, T.
Richart, T.
Thijs, L.
NAWROT, Tim
Yu, J.
Segers, P.
Kuznetsova, T.
Balkestein, J.
Struijker-Boudier, H. A.
Staessen, J. A.
Issue Date: 2010
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: JOURNAL OF HYPERTENSION, 28. p. E129-E129
Abstract: Objective: Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure and arterial calcification. We hypothesized that lower calcium intake as reflected by circulating PTH and 25-OH-D3 might be associated with the metabolic syndrome (MS) and arterial calcification. Design and method: In a random population sample (n = 542; 50.5% women; mean age, 49.8 13.1 years), we measured MS prevalence (IDF and AHA criteria), PTH and 25-OH-D3, serum and 24-h urinary calcium, MS components, carotid intima-media thickness (CIMT) and calcium intake from dairy products. We assessed associations in multivariable-adjusted analyses, using linear and logistic regressions. Results: The prevalence of MS was 21.0% (IDF criteria) and 23.6% (AHA criteria). MS prevalence, blood pressure, waist circumference, body mass index, fasting blood glucose, insulin and triglycerides, and CIMT increased (P<0.042) across quartiles of the PTH/25-OH-D3 ratio, whereas serum and 24-h urinary calcium decreased (P<0.029). Waist circumference and fasting blood glucose decreased across quartiles of habitual calcium intake (P<0.04). In models that included MS (IDF) and PTH/25-OH-D3, the regression coefficients for PTH/25-OH-D3 ratio and MS were +51.3-m (P = 0.013) and +18.9-m (P = 0.45), respectively. Multivariable adjusted analyses were confirmatory. Conclusions: MS prevalence and CIMT were positively associated with PTH/25-OH-D3. CIMT was not associated with MS In the presence of PTH/25-OH-D3. Assuming causal and reversible associations, a high dietary calcium intake might protect against arterial calcification and MS.
Notes: [Richart, T.; Thijs, L.; Yu, J.; Kuznetsova, T.; Staessen, J. A.] Studies Coordinating Ctr, Div Hypertens & Cardiovasc Rehabil, Dept Cardiovasc Dis, Leuven, Belgium. [Richart, T.; Staessen, J. A.] Maastricht Univ, Dept Epidemiol, Genet Epidemiol Unit, Maastricht, Netherlands. [Nawrot, T.] Univ Hasselt, Lab Biol & Geol, Dept Chem Biol & Geol, Hasselt, Belgium. [Segers, P.] Univ Ghent, Cardiovasc Mech & Biofluid Dynam Res Grp, IBiTech, B-9000 Ghent, Belgium. [Balkestein, J.; Struijker-Boudier, H. A.] Maastricht Univ, Dept Pharmacol, Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/11593
ISI #: 000283023402272
ISSN: 0263-6352
Category: M
Type: Journal Contribution
Appears in Collections: Research publications

Files in This Item:

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.