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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11550

Title: Memory CD4(+)CD127(high) T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens
Authors: VENKEN, Koen
HELLINGS, Niels
HENSEN, Karen
RUMMENS, Jean-Luc
STINISSEN, Piet
Issue Date: 2010
Publisher: ELSEVIER SCIENCE BV
Citation: JOURNAL OF NEUROIMMUNOLOGY, 226 (1-2). p. 185-191
Abstract: Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MUG) and tetanus toxoid (TT). Proliferative responses of Tconv cells towards MBP, MUG and TT were not significantly different between MS patients and HC. However, MBP and MUG but not TT reactive memory Tconv cells from MS patients, in contrast to HC, produced IL-17. These results suggest that myelin antigen reactive Th-17 cells are enriched in MS patients. (C) 2010 Elsevier B.V. All rights reserved.
Notes: [Venken, Koen] Ghent Univ Hosp, Dept Rheumatol, Lab Mol Immunol & Inflammat, B-9000 Ghent, Belgium. [Venken, Koen; Hellings, Niels; Stinissen, Piet] Hasselt Univ, Biomed Onderzoeksinst, Diepenbeek, Belgium. [Venken, Koen; Hellings, Niels; Stinissen, Piet] Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. [Hensen, Karen; Rummens, Jean-Luc] Virga Jesse Hosp, Clin Lab Expt Hematol, Hasselt, Belgium. koen.venken@ugent.be
URI: http://hdl.handle.net/1942/11550
DOI: 10.1016/j.jneuroim.2010.05.025
ISI #: 000282545500026
ISSN: 0165-5728
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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