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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11530

Title: Continuous endurance-type exercise training does not modulate satellite cell content in obese type 2 diabetes patients
Authors: Snijders, Tim
Verdijk, Lex
HANSEN, Dominique
van Loon, Luc
Issue Date: 2011
Publisher: Wiley
Citation: MUSCLE & NERVE, 43(3), p. 393-401
Abstract: Endurance-type exercise training represents a cornerstone in type 2 diabetes treatment. However, the effects of prolonged continuous, endurance-type exercise on muscle fiber characteristics remain equivocal. Fifteen obese male type 2 diabetes patients (61 ± 6 years) participated in a 6-month continuous, endurance-type exercise program. Muscle biopsies were collected before, and after 2 and 6 months of intervention. Muscle fiber type–specific composition, size, and satellite cell (SC) and myonuclear content were determined by immunohistochemistry. Although continuous endurance-type exercise training lowered total body weight and reduced fat mass, no changes were observed in leg lean mass. At baseline, SC content was significantly lower in type II compared with type I muscle fibers. No change in SC content was observed after exercise training. Continuous endurance-type exercise training lowers fat mass, but it does not increase leg lean mass and/or modulate muscle fiber characteristics in type 2 diabetes patients.
URI: http://hdl.handle.net/1942/11530
DOI: 10.1002/mus.21891
ISI #: 000287785600012
ISSN: 0148-639X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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