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|Title: ||Therapeutic potential of LIF in multiple sclerosis|
|Authors: ||SLAETS, Leen|
Hendriks, Jerome J. A.
Kilpatrick, Trevor J.
|Issue Date: ||2010|
|Publisher: ||ELSEVIER SCI LTD|
|Citation: ||TRENDS IN MOLECULAR MEDICINE, 16 (11). p. 493-500|
|Abstract: ||Therapies for multiple sclerosis (MS) reduce the relapse rate but are unable to stop neurological decline. Here, we evaluate the potential of leukemia inhibitory factor (LIF) as a novel therapeutic in diseases with a neurodegenerative and inflammatory component, such as MS. LIF, which can be a proinflammatory cytokine, can also modulate the immune response in a beneficial way. Recent evidence demonstrates a crucial role of LIF in neuroprotection and axonal regeneration as well as the prevention of demyelination. Finally, LIF is an important survival factor for stem cells and neuronal precursors. Therefore, we propose that LIF is a potential therapeutic candidate for MS.|
|Notes: ||[Slaets, Helena; Hendriks, Jerome J. A.; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium. [Slaets, Helena; Hendriks, Jerome J. A.; Stinissen, Piet; Hellings, Niels] Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. [Kilpatrick, Trevor J.] Univ Melbourne, Ctr Neurosci, Melbourne, Vic 3010, Australia. [Kilpatrick, Trevor J.] Univ Melbourne, Howard Florey Inst, Melbourne, Vic 3010, Australia.
|ISI #: ||000284729500001|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2011|
|Appears in Collections: ||Research publications|
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