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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11467

Title: Therapeutic potential of LIF in multiple sclerosis
Authors: SLAETS, Leen
Hendriks, Jerome J. A.
STINISSEN, Piet
Kilpatrick, Trevor J.
HELLINGS, Niels
Issue Date: 2010
Publisher: ELSEVIER SCI LTD
Citation: TRENDS IN MOLECULAR MEDICINE, 16 (11). p. 493-500
Abstract: Therapies for multiple sclerosis (MS) reduce the relapse rate but are unable to stop neurological decline. Here, we evaluate the potential of leukemia inhibitory factor (LIF) as a novel therapeutic in diseases with a neurodegenerative and inflammatory component, such as MS. LIF, which can be a proinflammatory cytokine, can also modulate the immune response in a beneficial way. Recent evidence demonstrates a crucial role of LIF in neuroprotection and axonal regeneration as well as the prevention of demyelination. Finally, LIF is an important survival factor for stem cells and neuronal precursors. Therefore, we propose that LIF is a potential therapeutic candidate for MS.
Notes: [Slaets, Helena; Hendriks, Jerome J. A.; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium. [Slaets, Helena; Hendriks, Jerome J. A.; Stinissen, Piet; Hellings, Niels] Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. [Kilpatrick, Trevor J.] Univ Melbourne, Ctr Neurosci, Melbourne, Vic 3010, Australia. [Kilpatrick, Trevor J.] Univ Melbourne, Howard Florey Inst, Melbourne, Vic 3010, Australia. 000284729500001
URI: http://hdl.handle.net/1942/11467
DOI: 10.1016/j.molmed.2010.08.007
ISI #: 000284729500001
ISSN: 1471-4914
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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