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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11449

Title: Bronchoalveolar lavage neutrophilia in acute lung allograft rejection and lymphocytic bronchiolitis
Authors: Vos, Rob.
Vanaudenaerde, Bart M.
Verleden, Stijn E.
De Vleeschauwer, Stephanie I.
Willems-Widyastuti, Anna
Van Raemdonck, Dirk E.
Dupont, Lieven J.
Verbeken, Erik K.
Verleden, Geert M.
Issue Date: 2010
Abstract: BACKGROUND: Acute cellular rejection and lymphocytic bronchiolitis can impair allograft function after lung transplant (LTx). Both may be refractory to corticosteroid treatment. We hypothesized that bronchoalveolar lavage (BAL) neutrophilia may be increased in either acute rejection or lymphocytic bronchiolitis or may increase with increasing histologic severity. METHODS: All consecutive BAL with subsequent transbronchial biopsy (TBB) specimens, performed in 339 LTx recipients from 2001 to 2008, were retrospectively analyzed. TBB specimens were classified according to histologic grade with analysis of BAL total cell count and cell differentials. RESULTS: The analysis included 768 TBB specimens. After adjustment for possible confounders, BAL total cell count significantly increased both with grade A or B severity (p < 0.0001). A higher A grade was characterized by a significant increase in BAL lymphocytosis and neutrophilia (p < 0.0001), whereas for higher B grades, only a more prominent BAL neutrophilia was seen (p < 0.0001). CONCLUSIONS: Higher grade A, but, particularly, higher grade B severity scores are characterized by increased BAL neutrophilia. J Heart Lung Transplant 2010;29:1259-69 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved.
Notes: [Verleden, Geert M.] Univ Hosp Gasthuisberg, Lung Transplantat Unit, B-3000 Louvain, Belgium. [Vos, Robin; Vanaudenaerde, Bart M.; Verleden, Stijn E.; De Vleeschauwer, Stephanie I.; Willems-Widyastuti, Anna; Dupont, Lieven J.; Verleden, Geert M.] Katholieke Univ Leuven, Lab Pneumol, Louvain, Belgium. [Van Raemdonck, Dirk E.] Katholieke Univ Leuven, Lab Expt Thorac Surg, Louvain, Belgium. [Van Raemdonck, Dirk E.; Dupont, Lieven J.; Verleden, Geert M.] Katholieke Univ Leuven, Lung Transplantat Unit, Louvain, Belgium. [Nawrot, Tim S.] Univ Hasselt, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim S.] Katholieke Univ Leuven, Sch Publ Hlth, Unit Lung Toxicol Occupat & Environm Med, Louvain, Belgium. [Verbeken, Erik K.] Katholieke Univ Leuven, Dept Histol, Louvain, Belgium.
URI: http://hdl.handle.net/1942/11449
DOI: 10.1016/j.healun.2010.05.019
ISI #: 000284030700009
ISSN: 1053-2498
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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