www.uhasselt.be
DSpace

Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11432

Title: Contributions of meta-analyses based on individual patient data to therapeutic progress in colorectal cancer
Authors: BUYSE, Marc
Issue Date: 2009
Publisher: SPRINGER TOKYO
Citation: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 14 (2). p. 95-101
Abstract: Meta-analysis is the statistical process of combining information from several studies addressing the same question. Meta-analyses based on individual patient data are far more reliable and informative than those based on summary statistics obtained from the trialists or extracted from the published literature. Meta-analysis of randomized clinical trials may contribute to therapeutic progress through (1) establishing efficacy benefits beyond a reasonable doubt, (2) identifying sources of heterogeneity between trials, (3) studying subsets reliably, (4) confirming differences in toxicity profiles, (5) evaluating the cost-effectiveness of experimental therapies, (6) assessing surrogate endpoints, and (7) addressing ancillary questions. All of these potential contributions are illustrated with examples in early and advanced colorectal cancer.
Notes: [Buyse, Marc] Int Inst Drug Dev, Louvain, Belgium. [Buyse, Marc] Hasselt Univ, Ctr Stat, Diepenbeek, Belgium. marc.buyse@iddi.com
URI: http://hdl.handle.net/1942/11432
DOI: 10.1007/s10147-009-0879-2
ISI #: 000265498500004
ISSN: 1341-9625
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

Files in This Item:

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.