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|Title: ||Contributions of meta-analyses based on individual patient data to therapeutic progress in colorectal cancer|
|Authors: ||BUYSE, Marc|
|Issue Date: ||2009|
|Publisher: ||SPRINGER TOKYO|
|Citation: ||INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 14 (2). p. 95-101|
|Abstract: ||Meta-analysis is the statistical process of combining information from several studies addressing the same question. Meta-analyses based on individual patient data are far more reliable and informative than those based on summary statistics obtained from the trialists or extracted from the published literature. Meta-analysis of randomized clinical trials may contribute to therapeutic progress through (1) establishing efficacy benefits beyond a reasonable doubt, (2) identifying sources of heterogeneity between trials, (3) studying subsets reliably, (4) confirming differences in toxicity profiles, (5) evaluating the cost-effectiveness of experimental therapies, (6) assessing surrogate endpoints, and (7) addressing ancillary questions. All of these potential contributions are illustrated with examples in early and advanced colorectal cancer.|
|Notes: ||[Buyse, Marc] Int Inst Drug Dev, Louvain, Belgium. [Buyse, Marc] Hasselt Univ, Ctr Stat, Diepenbeek, Belgium.
|ISI #: ||000265498500004|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2010|
|Appears in Collections: ||Research publications|
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