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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11380

Title: Evaluation of Molecular Assays for Rapid Detection of Methicillin-Resistant Staphylococcus aureus
Authors: Malhotra-Kumar, Surbhi
Van Heirstraeten, Liesbet
Lee, Andie
Cortinas Abrahantas, Jose
Lammens, Christine
Vanhommerig, Evelyn
Molenberghs, Geert
Aerts, Marc
Harbarth, Stephan
Goossens, Herman
Issue Date: 2010
Citation: JOURNAL OF CLINICAL MICROBIOLOGY, 48(12). p. 4598-4601
Abstract: The diagnostic sensitivities of the BD GeneOhm and Cepheid Xpert assays were compared using culture on log-serial dilutions of well-characterized methicillin-resistant Staphylococcus aureus (MRSA) and non-MRSA strains and on nasal and groin swabs from patients with histories of MRSA carriage. The sensitivities of GeneOhm and Xpert were high at 10(3)-CFU/ml MRSA concentrations (92.3% and 96.3%, respectively) although decreased considerably (< 35%) at a 1-log-lower concentration. Unexpectedly, both assays also detected select coagulase-negative staphylococci, which requires further evaluation.
Notes: [Malhotra-Kumar, Surbhi; Van Heirstraeten, Liesbet; Lammens, Christine; Vanhommerig, Evelyn; Goossens, Herman] Univ Antwerp, Dept Med Microbiol, Antwerp, Belgium. [Malhotra-Kumar, Surbhi; Van Heirstraeten, Liesbet; Lammens, Christine; Vanhommerig, Evelyn; Goossens, Herman] Univ Antwerp, Vaccine & Infect Dis Inst, Antwerp, Belgium. [Lee, Andie; Harbarth, Stephan] Univ Hosp Geneva, Geneva, Switzerland. [Lee, Andie; Harbarth, Stephan] Univ Geneva, Sch Med, CH-1211 Geneva, Switzerland. [Abrahantes, Jose Cortinas; Molenberghs, Geert; Aerts, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/11380
DOI: 10.1128/JCM.00004-10
ISI #: 000284693400042
ISSN: 0095-1137
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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