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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11279

Title: Cadmium stress: an oxidative challenge
Authors: Cuypers, Ann
Plusquin, Michelle
Remans, Tony
Jozefczak, Marijke
Keunen, Els
Gielen, Heidi
Opdenakker, Kelly
Ravindran Nair, Ambily
Munters, Elke
Artois, Tom J.
Nawrot, Tim S.
Vangronsveld, Jaco
Smeets, Kelly
Issue Date: 2010
Publisher: Springer Netherlands
Citation: BIOMETALS, 23(5). p. 927-940
Abstract: At the cellular level, cadmium (Cd) induces both damaging and repair processes in which the cellular redox status plays a crucial role. Being not redox-active, Cd is unable to generate reactive oxygen species (ROS) directly, but Cd-induced oxidative stress is a common phenomenon observed in multiple studies. The current review gives an overview on Cd-induced ROS production and anti-oxidative defense in organisms under different Cd regimes. Moreover, the Cd-induced oxidative challenge is discussed with a focus on damage and signaling as downstream responses. Gathering these data, it was clear that oxidative stress related responses are affected during Cd stress, but the apparent discrepancies observed in between the different studies points towards the necessity to increase our knowledge on the spatial and temporal ROS signature under Cd stress. This information is essential in order to reveal the exact role of Cd-induced oxidative stress in the modulation of downstream responses under a diverse array of conditions.
URI: http://hdl.handle.net/1942/11279
DOI: 10.1007/s10534-010-9329-x
ISI #: 000283079200010
ISSN: 0966-0844
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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