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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11219

Title: The auto-antigen repertoire in myasthenia gravis
Authors: Vrolix, Kathleen
Molenaar, Peter C.
Losen, Mario
SOMERS, Veerle
Martinez-Martinez, Pilar
Issue Date: 2010
Citation: AUTOIMMUNITY, 43 (5-6). p. 380-400
Abstract: Myasthenia Gravis (MG) is an antibody-mediated autoimmune disorder affecting the postsynaptic membrane of the neuromuscular junction (NMJ). MG is characterized by an impaired signal transmission between the motor neuron and the skeletal muscle cell, caused by auto-antibodies directed against NMJ proteins. The auto-antibodies target the nicotinic acetylcholine receptor (nAChR) in about 90% of MG patients. In approximately 5% of MG patients, the muscle specific kinase (MuSK) is the auto-antigen. In the remaining 5% of MG patients, however, antibodies against the nAChR or MuSK are not detectable (idiopathic MG, iMG). Although only the anti-nAChR and anti-MuSK auto-antibodies have been demonstrated to be pathogenic, several other antibodies recognizing self-antigens can also be found in MG patients. Various auto-antibodies associated with thymic abnormalities have been reported, as well as many non-MG-specific auto-antibodies. However, their contribution to the cause, pathology and severity of the disease is still poorly understood. Here, we comprehensively review the reported auto-antibodies in MG patients and discuss their role in the pathology of this autoimmune disease.
Notes: [Martinez-Martinez, Pilar] Maastricht Univ, Sch Mental Hlth & Neurosci, Fac Hlth Med & Life Sci, Dept Neurosci,Neuroimmunol Grp,Div Neurosci, NL-6200 MD Maastricht, Netherlands. [Fraussen, Judith; Somers, Veerle; Stinissen, Piet; De Baets, Marc H.] Hasselt Univ, Sch Life Sci, Biomed Res Inst, Diepenbeek, Belgium. [Fraussen, Judith; Somers, Veerle; Stinissen, Piet; De Baets, Marc H.] Hasselt Univ, Transnatl Univ Limburg, Diepenbeek, Belgium. p.martinez@maastrichtuniversity.nl
URI: http://hdl.handle.net/1942/11219
DOI: 10.3109/08916930903518073
ISI #: 000281961100005
ISSN: 0891-6934
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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