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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11127

Title: Synthetic Exploration of Oxacalix[2]arene[2]quinazolines
Authors: Van Rossom, Wim
Kishore, Lingam
Robeyns, Koen
Van Meervelt, Luc
Dehaen, Wim
MAES, Wouter
Issue Date: 2010
Publisher: WILEY-V C H VERLAG GMBH
Citation: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (21). p. 4122-4129
Abstract: Oxacalix[2]arene[2]quinazoline macrocycles were prepared in good yields, as mixtures of syn and anti isomers, through nucleophilic aromatic substitution cyclocondensation reactions of 2,4-dichloroquinazolines and m-dihydroxybenzenes. The macrocyclization conditions were optimized and the isomeric ratio was investigated by means of one-step and fragment-coupling approaches. The oxacalixarene substitution pattern could easily be varied by altering the dichloroquinazolinyl biselectrophilic and dihydroxyaryl bisnucleophilic building blocks. The solid-state (1,3-alternate) conformational behavior and the oxacalix[4]arene cavity size were explored by X-ray diffraction studies.
Notes: [Van Rossom, Wim; Kishore, Lingam; Robeyns, Koen; Van Meervelt, Luc; Dehaen, Wim; Maes, Wouter] Katholieke Univ Leuven, Dept Chem, B-3001 Louvain, Belgium. [Maes, Wouter] Hasselt Univ, Inst Mat Res IMO, Res Grp Organ & BioPolymer Chem, B-3590 Diepenbeek, Belgium. wim.dehaen@chem.kuleuven.be
URI: http://hdl.handle.net/1942/11127
DOI: 10.1002/ejoc.201000460
ISI #: 000280729500017
ISSN: 1434-193X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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