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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11112

Title: MIP-based sensor platforms for the detection of histamine in the nano- and micromolar range in aqueous media
Authors: HOREMANS, Frederik
Alenus, Jan
BONGAERS, Evi
WEUSTENRAED, Ans
THOELEN, Ronald
DUCHATEAU, Jan
LUTSEN, Laurence
VANDERZANDE, Dirk
WAGNER, Patrick
CLEIJ, Thomas
Issue Date: 2010
Publisher: ELSEVIER SCIENCE SA
Citation: SENSORS AND ACTUATORS B-CHEMICAL, 148(2). p. 392-398
Abstract: The need for more advanced, accurate and lower cost sensor platforms is constantly growing. However, for certain applications the already existing sensing systems based on biological recognition elements have sometimes restrictions, which limit their use. As a result, sensors with synthetic recognition elements, such as molecular imprinted polymers (MIPs), can be interesting alternatives. Molecular imprinting leads to the formation of inert polymer particles with nanocavities, which can exhibit similar selectivity and specificity to target molecules as' antibodies or enzymes. It is demonstrated that MIPs can be readily incorporated into two different sensor platforms for the detection of histamine in aqueous media. The first platform is based on electrochemical impedance spectroscopy and allows for the accurate detection of histamine in the nanomolar range. The second sensing technique is based on microgravimetry and allows for the detection of histamine in the micromolar range. Using the analogous molecule histidine, it is demonstrated that both sensor platforms are specific for the detection of histamine. (C) 2010 Elsevier B.V. All rights reserved.
Notes: [Horemans, F.; Alenus, J.; Bongaers, E.; Weustenraed, A.; Duchateau, J.; Vanderzande, D.; Wagner, P.; Cleij, T. J.] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Thoelen, R.] XIOS Univ Coll, B-3590 Diepenbeek, Belgium. [Lutsen, L.; Vanderzande, D.; Wagner, P.] IMEC, Div IMOMEC, B-3590 Diepenbeek, Belgium. thomas.cleij@uhasselt.be
URI: http://hdl.handle.net/1942/11112
DOI: 10.1016/j.snb.2010.05.003
ISI #: 000280382200008
ISSN: 0925-4005
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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