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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11098

Title: The Metabolic Syndrome and Carotid Intima-Media Thickness in Relation to the Parathyroid Hormone to 25-OH-D(3) Ratio in a General Population.
Authors: Richart, Tom
Thijs, Lutgarde
Yu, Jin
Kuznetsova, Tatiana
Balkestein, Elisabeth J.
Struijker-Boudier, Harry A.
Staessen, Jan A.
Issue Date: 2010
Publisher: Nature Publishing Group
Citation: AMERICAN JOURNAL OF HYPERTENSION, 24(1). p. 102-109
Abstract: Backgound: Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure, and arterial calcification. We hypothesized that lower calcium intake as reflected by circulating PTH and 25-OH-D3 might be associated with the metabolic syndrome (MS) and arterial calcification. Methods: In a random population sample (n = 542; 50.5% women; mean age, 49.8 ± 13.1 years), we measured MS prevalence (International Diabetes Federation (IDF) and American Heart Association (AHA) criteria), PTH and 25-OH-D3, serum and 24-h urinary calcium, MS components, carotid intima-media thickness (CIMT), and calcium intake from dairy products. We assessed associations in multivariable-adjusted analyses, using linear and logistic regressions. Results: The prevalence of MS was 21.0% (IDF criteria) and 23.6% (AHA criteria). MS prevalence, blood pressure, waist circumference, body mass index, fasting blood glucose, insulin and triglycerides, and CIMT increased (P = 0.042) across quartiles of the PTH/25-OH-D3 ratio, whereas serum and 24-h urinary calcium decreased (P = 0.029). Waist circumference and fasting blood glucose decreased across quartiles of habitual calcium intake (P = 0.04). In models that included MS (IDF) and PTH/25-OH-D3, the regression coefficients relating CIMT to PTH/25-OH-D3 ratio and MS were +51 µm (P = 0.013) and +19 µm (P = 0.45), respectively. Multivariable-adjusted analyses were confirmatory. Conclusions: MS prevalence and CIMT were positively associated with PTH/25-OH-D3. CIMT was not associated with MS. Prospective studies and intervention trials should address the causality of these associations.
Notes: [Richart, Tom; Yu, Jin; Staessen, Jan A.] Maastricht Univ, Dept Epidemiol, Genet Epidemiol Unit, Maastricht, Netherlands.[Richart, Tom; Thijs, Lutgarde; Kuznetsova, Tatiana; Staessen, Jan A.] Univ Leuven, Studies Coordinating Ctr, Div Hypertens & Cardiovasc Rehabil, Dept Cardiovasc Dis, Louvain, Belgium. [Nawrot, Tim] Univ Hasselt, Lab Biol & Geol, Dept Chem Biol & Geol, Hasselt, Belgium. [Balkestein, Elisabeth J.; Struijker-Boudier, Harry A.] Maastricht Univ, Dept Pharmacol, Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/11098
DOI: 10.1038/ajh.2010.124
ISI #: 000285501800017
ISSN: 0895-7061
Category: A1
Type: Journal Contribution
Validation: ecoom, 2012
Appears in Collections: Research publications

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