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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11027

Title: POLY 293-Development of a novel biosensor platform based on a combination of molecularly imprinted polymers (MIPs) and conjugated polymers
Authors: THOELEN, Ronald
DUCHATEAU, Jan
HOREMANS, Frederik
VANSWEEVELT, Rob
LUTSEN, Laurence
VANDERZANDE, Dirk
WAGNER, Patrick
CLEIJ, Thomas
Issue Date: 2008
Publisher: AMER CHEMICAL SOC
Citation: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 235. p. 293-POLY-...
Abstract: Molecular imprinted polymers(MPIs) attract considerable interest as synthetic materials mimicking molecular recognition of natural receptors. However, integration of MIPs in clinical diagnostics is difficult because of limitations involving the integration of MIPs with transducers and the transformation of binding events into measurable signals. As a universal solution to these limitations a novel biosensor platform has been developed, in which the readout is achieved using impedance spectroscopy. To obtain a measurable electronic readout, a thin film of the conjugated polymer(OC1 C10-PPV)is used to immobilize the non conducting MIP particles onto the electrode surface. As a proof of principle, a MIP-based sensor for L-nicotine has been prepared. It is demonstrated that in this novel sensor, it is possible to detect L-nicotine in nano-molecular concentrations, whereas no response is observed for L-cotinine. It is anticipated that ourn novel biosensor platform can be useful in many applications, such as clinical diagnostics.
Notes: [Thoelen, Ronald; Duchateau, Jan; Horemans, Frederik; Vansweevelt, Rob; Vanderzande, Dirk; Wagner, Patrick; Cleij, Thomas J.] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Lutsen, Laurence] IMEC, Div IMOMEC, B-3590 Diepenbeek, Belgium. thomas.cleij@uhasselt.be
URI: http://hdl.handle.net/1942/11027
ISI #: 000271802800416
ISSN: 0065-7727
Category: M
Type: Journal Contribution
Appears in Collections: Research publications

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