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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11015

Title: Cadmium and transport of ions and substances across cell membranes and epithelia.
Authors: VAN KERKHOVE, Emmy
SWENNEN, Quirine
Issue Date: 2010
Publisher: Springer
Citation: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 23(5). p. 823-855
Abstract: Toxic metals such as cadmium (Cd(2+)) pose serious risks to human health. However, even though the importance of Cd(2+) as environmental health hazards is now widely appreciated, the specific mechanisms by which it produces its adverse effects have yet to be fully elucidated. Cd(2+) is known to enter cells, it binds and interacts with a multitude of molecules, it may indirectly induce oxidative stress and interfere with gene expression and repair of DNA. It also interacts with transport across cell membranes and epithelia and may therefore disturb the cell's homeostasis and function. Interaction with epithelial transport, especially in the kidney and the liver, may have serious consequences in general health. A lot of research still needs to be done to understand the exact way in which Cd(2+) interferes with these transport phenomena. It is not always clear whether Cd(2+) has primary or secondary effects on cell membrane transport. In the present review we try to summarize the work that has been done up to now and to critically discuss the relevance of the experimental work in vitro with respect to the in vivo situation.
Notes: Department of Physiology, Faculty of Medicine, Centre for Environmental Sciences, Hasselt University, Agoralaan, Building C, B3590, Diepenbeek, Belgium, emmy.vankerkhove@uhasselt.be.
URI: http://hdl.handle.net/1942/11015
DOI: 10.1007/s10534-010-9357-6
ISI #: 000283079200006
ISSN: 0966-0844
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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