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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/11011

Title: The Impact of Air Pollution on Bronchiolitis Obliterans Syndrome and Mortality after Lung Transplantation
Authors: Vanaudenaerde, B.
Vos, R.
Verleden, S.
Jacobs, L.
FAES, Christel
Hoet, P.
Van Raemdonck, D.
Dupont, L.
Nemery, B.
Verleden, G.
Issue Date: 2010
Abstract: Background: Approximately half of all patients who underwent a lung transplantation suffer from bronchiolitis obliterans syndrome(BOS), the clinical correlate of chronic rejection, within 5 years after transplantation. This prevalence is much higher than for other solid organ transplantations, possibly due to the lung's direct contact with the environment. The authors assessed the association between proximity of the home to major roads and BOS and mortaility in a cohort of patients after lung transplantation. Methods: The authors calculated hazard ratios for BOS and mortality in relation to proximity of the home to major roads, adjusting for relevant covariables, in 288 patients after lung transplantation at the Leuven University Hospital between 1997 and 2009 and with follow-up until August 2009. Inflammatory parameters in plasma and bronchoalveolar lavage were assessed in 207 patients. Results: During follow-up,117 (41%) patients developed BOS and 61 (21%) died. Patients who lived within 171 m of a major road (lowest tertile) were 2.06 (95% CI 1.39 to 3.05) times more likely to develop BOS and 2.20 (1.25 to 3.86) times more likely to die than patients living farther away. The adjusted hazard ratios of BOS and mortality were 0.57 and 0.72 for each 10-fold increase in distance from major roads. Proximity to a major road was inversely associated with plasma C-reactive protein levels, neutrophil percentage and interleukin-6 concentration in bronchoalveolar lavage. Conclusion: Traffic-related air pollution appaers to constitute a serious risk of BOS and mortality after lung transplantation.
Notes: [Vanaudenaerde, B.; Vos, R.; Verleden, S.; Van Raemdonck, D.; Dupont, L.; Verleden, G.] Univ Ziekenhuis Gasthuisberg, Louvain, Belgium. [Vanaudenaerde, B.; Nawrot, T.; Vos, R.; Verleden, S.; Jacobs, L.; Hoet, P.; Van Raemdonck, D.; Dupont, L.; Nemery, B.; Verleden, G.] Katholieke Univ Leuven, Louvain, Belgium. [Nawrot, T.; Faes, C.] Univ Hasselt, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/11011
ISI #: 000274756100272
ISSN: 1053-2498
Category: M
Type: Journal Contribution
Appears in Collections: Research publications

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