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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10886

Title: Long-term effect of rehabilitation in coronary artery disease patients: randomized clinical trial of the impact of exercise volume
Authors: HANSEN, Dominique
Raskin, Anita
Schoonis, Annick
Berger, Jan
Vlassak, Irmien
Meeusen, Romain
Issue Date: 2010
Citation: CLINICAL REHABILITATION, 24 (4). p. 319-327
Abstract: Objective: To assess whether exercise volume during phase II rehabilitation affects long-term clinical benefits in patients with coronary artery disease. Design: Prospective randomized clinical trial with long-term follow-up. Setting: Hospital outpatient clinic. Subjects: Coronary artery disease patients (age 65 +/- 9 years, 82% males) attending a phase II rehabilitation programme were randomized into two groups of exercise volumes: 40-versus 60-minute training sessions. Patients exercised for three days per week for seven weeks, at 65% of baseline oxygen uptake capacity. Next, they were followed up for 18 months. Out of 165 patients with coronary artery disease who completed the exercise intervention, 119 attended the 18-month follow-up assessment. Main measurements: Body anthropometrics, resting haemodynamics, blood lipid profile, glycaemia, and C-reactive protein level, smoking behaviour, habitual physical activity, cardiovascular disease incidence and mortality. Results: In total population, a significant worsening of various cardiovascular disease risk factors was found at 18 months follow-up (P<0.05), and few patients (27% of total group) adhered to the recommended minimal physical activity level. No difference in change of body anthropometrics, resting haemodynamics, blood lipid profile, glycaemia, and C-reactive protein level, and smoking behaviour was seen between different exercise volumes (P>0.05). In addition, total cardiovascular disease incidence (13% versus 22% in 40-versus 60-minute group, respectively) and habitual physical activity were not different between groups (P>0.05). Conclusion: In patients with coronary artery disease following cardiac rehabilitation, the cardiovascular disease risk profile worsened significantly during long-term follow-up. A smaller exercise volume during phase II rehabilitation generated equal long-term clinical benefits compared to a greater exercise volume.
Notes: [Meeusen, Romain] Vrije Univ Brussels, Fac LK, Dept Human Physiol & Sportsmed, B-1050 Brussels, Belgium. [Hansen, Dominique; Dendale, Paul; Raskin, Anita; Schoonis, Annick; Berger, Jan; Vlassak, Irmien] Jessa Hosp, Rehabil & Hlth Ctr, Heart Ctr Hasselt, Hasselt, Belgium. [Dendale, Paul] Hasselt Univ, Fac Med, Diepenbeek, Belgium. rmeeusen@vub.ac.be
URI: http://hdl.handle.net/1942/10886
DOI: 10.1177/0269215509353262
ISI #: 000276174500004
ISSN: 0269-2155
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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