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|Title: ||SLIDER: Mining correlated motifs in protein-protein interaction networks|
|Authors: ||BOYEN, Peter|
VAN DYCK, Dries
van Dijk, Aalt D.J.
Van Ham, Roeland C.J.H.
|Issue Date: ||2009|
|Publisher: ||IEEE Computer Society|
|Citation: ||Proceedings of the 9th IEEE International Conference on Data Mining (ICDM 2009). p. 716-721.|
|Abstract: ||Correlated motif mining (CMM) is the problem to find overrepresented pairs of patterns, called motif pairs, in interacting protein sequences. Algorithmic solutions for CMM thereby provide a computational method for predicting binding sites for protein interaction. In this paper, we adopt a motif-driven approach where the support of candidate motif pairs is evaluated in the network. We experimentally establish the superiority of the Chi-square-based support measure over other support measures. Furthermore, we obtain that CMM is an NP-hard problem for a large class of support measures (including Chi-square) and reformulate the search for correlated motifs as a combinatorial optimization problem. We then present the method SLIDER which uses local search with a neigborhood function based on sliding motifs and employs the Chi-square-based support measure. We show that SLIDER outperforms existing motif-driven CMM methods and scales to large protein-protein interaction networks.|
|Link to publication: ||http://doi.ieeecomputersociety.org/10.1109/ICDM.2009.92|
|ISI #: ||000287216600076|
|Type: ||Proceedings Paper|
|Validation: ||ecoom, 2012|
|Appears in Collections: ||Research publications|
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