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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10719

Title: Disturbed regulatory T cell homeostasis in multiple sclerosis.
Authors: VENKEN, Koen
HELLINGS, Niels
Liblau, Roland
STINISSEN, Piet
Issue Date: 2010
Publisher: Elsevier
Citation: TRENDS IN MOLECULAR MEDICINE, 16(2). p. 58-68
Abstract: The pathological features of multiple sclerosis (MS), a chronic inflammatory disorder of the central nervous system, support an autoimmune etiology. Strong evidence has been provided for a potential functional defect of CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) in patients with relapsing-remitting MS. More recently, alterations in homeostatic parameters related to the development and function of naive and memory-like Tregs were discovered in MS patients. In this review, we evaluate the evidence for disturbed Treg homeostasis in MS and discuss the role of potential compensatory mechanisms in the chronic disease phase. Better insights into the processes underlying the compromised immune regulation in MS patients will be important to understand the potential of Treg-based therapies.
Notes: Hasselt University, Biomedisch Onderzoeksinstituut and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium. koen.venken@ugent.be <koen.venken@ugent.be>
URI: http://hdl.handle.net/1942/10719
DOI: 10.1016/j.molmed.2009.12.003
ISI #: 000275541600002
ISSN: 1471-4914
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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