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|Title: ||The inhibitory neurotransmitter glycine modulates macrophage activity by activation of neutral amino acid transporters|
|Authors: ||CARMANS, Sofie|
VAN DEN EYNDEN, Jimmy
|Issue Date: ||2010|
|Citation: ||JOURNAL OF NEUROSCIENCE RESEARCH, 88(11). p. 2420-2430|
|Abstract: ||Glycine, an important inhibitory neurotransmitter in the mammalian central nervous system (CNS), has been shown to modulate peripheral immune cell responses. In that respect, glycine levels are
increased in several neuroinflammatory disorders, like amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). In this study, we show that glycine modulates macrophage effector functions implicated in CNS inflammation and in other related inflammatory conditions. We demonstrate that glycine does
not affect the production of reactive oxygen species, but stimulates myelin phagocytosis and the production of the pro-inflammatory mediators nitric oxide (NO) and tumor necrosis factor (TNF)-F by rat macrophages. These effects of glycine are not mediated by the glycine receptor (GlyR) or by glycine transporters (GlyTs), since neither the GlyR antagonist strychnine, nor the antagonist of GlyT1 (ALX5407) reverse the observed effects. In contrast, 2-aminoisobutyric acid, a substrate of neutral amino acid transporters (NAATs), inhibits the glycine-mediated enhancement of myelin phagocytosis as well as of NO and TNF-F production. In conclusion, our findings demonstrate that glycine modulates macrophage function through activation of NAATs. Glycine may thereby influence immunological processes in inflammatory diseases involving macrophage activation and demyelination, including MS, and related conditions associated with altered glycine levels.|
|Notes: ||[Hellings, Niels] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium.
RP Hellings, N, Hasselt Univ, Biomed Res Inst, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium.
|ISI #: ||000280436600011|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2011|
|Appears in Collections: ||Research publications|
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