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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10702

Title: Therapeutic vaccines for autoimmune Diseases
Authors: PANNEMANS, Kim
HELLINGS, Niels
STINISSEN, Piet
Issue Date: 2010
Publisher: Elsevier
Citation: Drug Discovery Today: Therapeutic Strategies, 6(1), p. 39-44
Abstract: The immune system has developed several checkpoints to prevent the induction of autoimmune diseases like multiple sclerosis and rheumatoid arthritis. Autoreactive T cells are negatively selected in the thymus but can escape this selection procedure. Peripherally, they are further controlled by homeostatic mechanisms and regulatory T cells (Tregs). Genetic and exogenous factors as well as a disbalanced functioning of Tregs may all influence these checkpoints and contribute to the breakdown of tolerance against ‘self’. Re-establishment of tolerance can be achieved by different vaccination strategies, which are divided into three major groups based on the composition of the vaccine: DNA vaccination, peptide-based-vaccination and T cell vaccination. This review summarizes the mechanisms, clinical trials and pros and cons of these different vaccination strategies.
URI: http://hdl.handle.net/1942/10702
DOI: 10.1016/j.ddstr.2009.11.001
ISSN: 1359-6446
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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