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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10471

Title: Organochlorine and heavy metals in newborns: Results from the Flemish Environment and Health Survey (FLEHS 2002-2006)
Authors: Koppen, Gudrun
Den Hond, Elly
Nelen, Vera
Van De Mieroop, Els
BRUCKERS, Liesbeth
Bilau, Maaike
Keune, Hans
Van Larebeke, Nicolas
Covaci, Adrian
Van De Weghe, Hendrik
Schroijen, Carmen
Desager, Kristine
Stalpaert, Michel
Baeyens, Willy
Schoeters, Greet
Issue Date: 2009
Citation: ENVIRONMENT INTERNATIONAL, 35(7). p. 1015-1022
Abstract: To collect regional information on internal levels of pollutants in humans in Flanders, 1196 mother-child pairs were systematically recruited in 2002-2003 via 25 maternities across Flanders. Cd, Pb, PCB congeners 118, 170, 138, 153 and 180, p,p'-DDE - a key metabolite of DDT- and hexachlorobenzene (HCB) were measured in cord blood or plasma. Cd was detected in 64% of the samples (geometric mean 0.21 mu g/L cord blood). p,p'-DDE (110 ng/g plasma lipids) and Pb (14.7 mu g/L blood), were measurable in nearly all samples. The individual PCB congeners could be detected in 40 to 81% of the newborns (138+153+180=64.4 ng/g plasma lipids). HCB (18.9 ng/g plasma lipids) and dioxin-like compounds measured by DR-CALUX (R) (23 pg CALUX-TEQ/g lipids) were above detection limit in more than 75% of the samples. Age and smoking habits of the mothers, did not influence the cord blood Pb and Cd levels. The organochlorines increased 4 to 9% per year of the mother's age (partial R-2=0.05 to 0.22). Mothers had 2.6% less PCBs in cord blood (partial R-2=0.02) for each unit increase in pre-pregnancy BMI. Season of delivery, breastfeeding previous children or consumption of local dairy products, were minor determinants. Up to 20% of the variability in organochlorine concentrations was explained by residence area. It was concluded that the place of birth in Flanders is an important determinant of the load of pollutants measured at the start of life. This underlines the validity of human biomonitoring on (relatively) small geographical scale. (C) 2009 Elsevier Ltd. All rights reserved.
Notes: [Koppen, Gudrun; Den Hond, Elly; Schoeters, Greet] Flemish Inst Technol Res, Toxicol Grp, Mol, Belgium. [Nelen, Vera; Van De Mieroop, Els] Prov Inst Hyg, Antwerp, Belgium. [Bruckers, Liesbeth] Katholieke Univ Leuven, Univ Hasselt, Interuniv Inst Biostat & Stat Bioinformat, Louvain, Belgium. [Bilau, Maaike] Univ Ghent, Dept Publ Hlth, Ghent, Belgium. [Keune, Hans] Univ Antwerp, Fac Polit & Social Sci, Antwerp, Belgium. [Van Larebeke, Nicolas] Univ Ghent, Dept Radiotherapy Nucl Med & Expt Oncol, Ghent, Belgium. [Covaci, Adrian] Univ Antwerp, Toxicol Ctr, Antwerp, Belgium. [Schroijen, Carmen; Baeyens, Willy] Vrije Univ Brussels, Dept Analyt & Environm Chem, Brussels, Belgium. [Desager, Kristine] Univ Antwerp Hosp, Antwerp, Belgium. [Stalpaert, Michel] AML Med Lab, Antwerp, Belgium. [Schoeters, Greet] Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium.
URI: http://hdl.handle.net/1942/10471
DOI: 10.1016/j.envint.2009.05.002
ISI #: 000270312600003
ISSN: 0160-4120
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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