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|Title: ||Measuring metacarpal cortical bone by digital x-ray radiogrammetry: a step forward?|
|Authors: ||GEUSENS, Piet|
Lems, Willem F.
|Issue Date: ||2009|
|Publisher: ||BIOMED CENTRAL LTD|
|Citation: ||ARTHRITIS RESEARCH & THERAPY, 11 (5)|
|Abstract: ||Changes in metacarpal cortical bone mineral density (BMD) using digital x-ray radiogrammetry were studied in patients with early rheumatoid arthritis. After 1, 2, and 5 years, large BMD losses were found: -1.7%, -2.8%, and -5.6%, respectively. Elevated erythrocyte sedimentation rate and anti-cyclic citrullinated peptide levels were independent predictors of bone loss, indicating that the largest amount of bone loss was found in patients with severe inflammation and high production of auto-antibodies, who are known to be at the highest risk of developing radiological bone damage. Studies are needed about the spatial and time relationship between erosions and juxta-articular and metacarpal bone loss.|
|Notes: ||[Geusens, Piet P.] Maastricht Univ, Med Ctr, Dept Internal Med, Subdiv Rheumatol, NL-6202 AZ Maastricht, Netherlands. [Geusens, Piet P.] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Lems, Willem F.] Vrije Univ Amsterdam, Med Ctr, Dept Rheumatol, NL-1007 MB Amsterdam, Netherlands.
|ISI #: ||000273338400004|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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