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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10444

Title: The Effect of Trabeculectomy on Ocular Pulse Amplitude
Authors: Breusegem, Christophe
FIEUWS, Steffen
Zeyen, Thierry
Stalmans, Ingeborg
Issue Date: 2010
Abstract: PURPOSE. To investigate whether trabeculectomy, besides its intraocular pressure (IOP)-lowering effect, has an effect on ocular pulse amplitude (OPA); and to determine whether OPA changes are influenced by IOP changes. METHODS. Forty-eight patients with glaucoma (48 eyes) scheduled for unilateral first-time trabeculectomy were prospectively enrolled from October 2007 to April 2008. The eye undergoing trabeculectomy was considered the study eye, whereas the nonsurgical fellow eye was used as the control eye. OPA, IOP, blood pressure, and heart rate were measured before and 4 weeks after trabeculectomy by means of Pascal dynamic contour tonometry (DCT), Goldmann applanation tonometry (GAT), and sphygmomanometry. A regression model for repeated measures was used. RESULTS. Preoperative GAT, DCT, and OPA were 20.92 +/- 8.55, 21.33 +/- 7.06, and 3.23 +/- 1.58 mm Hg, respectively. One month after trabeculectomy, GAT, DCT, and OPA were 11.23 +/- 5.03, 14.45 +/- 4.79, and 2.12 +/- 1.07 mm Hg, respectively. There was a significant decrease in OPA after filtration surgery in the study eye compared with the control eye (P < 0.0001). Changes in OPA were correlated with changes in IOP (Spearman rho = 0.49, P = 0.0004). When the IOP change caused by filtration surgery was taken into account, no significant difference in effect on OPA after trabeculectomy was demonstrated in the study eye compared with the control eye (P = 0.18). CONCLUSIONS. OPA changes correlated strongly with IOP changes. There was no evidence of an effect of filtration surgery on OPA when the concomitant IOP decrease after trabeculectomy was taken into account. (Invest Ophthalmol Vis Sci. 2010; 51:231-235) DOI:10.1167/iovs.09-3712
Notes: Stalmans, I (reprint author), Univ Hosp Leuven, Dept Ophthalmol, Campus St Rafael,Kapucijnenvoer 33, B-3000 Louvain, Belgium. [Breusegem, Christophe; Zeyen, Thierry; Stalmans, Ingeborg] Univ Hosp Leuven, Dept Ophthalmol, B-3000 Louvain, Belgium. [Fieuws, Steffen] Catholic Univ Louvain, I Biostat, Interuniv Inst Biostat & Stat Bioinformat, B-3000 Leuven, Belgium. [Fieuws, Steffen] Univ Hasselt, Hasselt, Belgium. ingeborg.stalmans@uzleuven.be
URI: http://hdl.handle.net/1942/10444
DOI: 10.1167/iovs.09-3712
ISI #: 000273264200034
ISSN: 0146-0404
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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