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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10426

Title: Analysis of antibody reactivity in paired cerebrospinal fluid and serum of a relapsing remitting multiple sclerosis patient
Authors: GOVARTS, Cindy
SOMERS, Klaartje
Hupperts, R.
SOMERS, Veerle
Issue Date: 2009
Citation: AUTOIMMUNITY, 42 (8). p. 699-704
Abstract: Increasing evidence indicates an involvement of B cells in multiple sclerosis (MS). However, little is known about antigenic targets recognized by antibodies present in blood and cerebrospinal fluid (CSF) of MS patients. This study was therefore aimed at identifying the antigen reactivity of antibodies present in CSF and compares the identified antibody profile with that of the serum of the same patient using cDNA phage display. Selection rounds on paired CSF and serum of this patient identified 13 antigenic targets of which 5 were enriched by serum antibodies and 2 were identified by CSF antibodies. Interestingly, the six remaining antigenic targets were shown to be recognized by both CSF and serum antibodies. These findings point towards both common as well as distinct antibody profiles in CSF and serum of MS patients.
Notes: [Somers, V.] Hasselt Univ, Biomed Res Inst, Sch Life Sci, Transnatl Univ Limburg, B-3590 Diepenbeek, Belgium. [Hupperts, R.] Maastricht Univ, Sch Mental Hlth & Neurosci, Med Ctr, Maastricht, Netherlands. [Hupperts, R.] Orbis Med Ctr, Dept Neurol, Sittard, Netherlands. veerle.somers@uhasselt.be
URI: http://hdl.handle.net/1942/10426
DOI: 10.3109/08916930903176513
ISI #: 000273447700008
ISSN: 0891-6934
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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