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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10387

Title: LAST OBSERVATION CARRIED FORWARD: A CRYSTAL BALL?
Authors: Kenward, Michael G.
Molenberghs, Geert
Issue Date: 2009
Publisher: TAYLOR & FRANCIS INC
Citation: JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 19 (5). p. 872-888
Abstract: In spite of widespread criticism and notwithstanding the availability of flexible, broadly valid, and conveniently implemented methods like direct-likelihood and direct-Bayesian analyses, last observation carried forward (LOCF), baseline observation carried forward (BOCF), and complete case analysis remain popular for handling incomplete clinical trial data. To the well-known criticisms toward LOCF and BOCF, namely, that they can be either conservative or liberal depending on the context, that they can violate the intention-to-treat principle, and so on, we add that, with the exception of certain degenerate and unrealistic special cases, these methods are incompatible with the sensible requirement that the mechanism governing dropout be independent of future, unobserved measurements, given covariates, past observed measurements, and the current possibly missing measurement.
Notes: [Molenberghs, Geert] Univ Hasselt, I BioStat, B-3590 Diepenbeek, Belgium. [Molenberghs, Geert] Katholieke Univ Leuven, I BioStat, Louvain, Belgium. [Kenward, Michael G.] London Sch Hyg & Trop Med, Med Stat Unit, London WC1, England. geert.molenberghs@uhasselt.be
URI: http://hdl.handle.net/1942/10387
DOI: 10.1080/10543400903105406
ISI #: 000273623200009
ISSN: 1054-3406
Category: A1
Type: Journal Contribution
Validation: ecoom, 2011
Appears in Collections: Research publications

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