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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10381

Title: Long-term behavioral outcome after early-life hyperthermia-induced seizures
Authors: LEMMENS, Evi
Aendekerk, Brenda
Schijns, Olaf E. M. G.
Blokland, Arjan
BEULS, Emile
Hoogland, Govert
Issue Date: 2009
Citation: EPILEPSY & BEHAVIOR, 14(2). p. 309-315
Abstract: Febrile seizures (FS) are among the most common types of seizures in the developing brain. It has been suggested that FS cause cognitive deficits that proceed into adulthood, but the information is conflicting. The aim of the present study was to determine whether experimental FS have long-term cognitive or behavioral deficits. FS were induced by hyperthermia (30 minutes, similar to 41 degrees C) in 10-day-old rat pups and, behavioral testing was performed. Hippocampus-dependent water maze learning, locomotor activity, and choice reaction time parameters (e.g., reaction time) were generally not affected by FS. However, more detailed analysis revealed that reaction times on the right side were slower than those on the left in controls, whereas this was not observed after FS. Early-life experimental FS did not cause overt cognitive and behavioral deficits, which is in line with previous work, but eliminated the lateralization effect in reaction time known to occur in normal controls, an effect that may be due to the combination of FS and kainic acid or to FS alone. (C) 2008 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/1942/10381
DOI: 10.1016/j.yebeh.2008.11.005
ISI #: 000263761600006
ISSN: 1525-5050
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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