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|Title: ||Potential role for ligand-gated ion channels after seizure-induced neurogenesis|
|Authors: ||SWIJSEN, Ann|
|Issue Date: ||2009|
|Publisher: ||PORTLAND PRESS LTD|
|Citation: ||BIOCHEMICAL SOCIETY TRANSACTIONS, 37. p. 1419-1422|
|Abstract: ||Epileptic seizures result in an increased generation of new neurons in the dentate gyrus of the adult mammalian hippocampus. The role of these seizure-induced newborn neurons in the process of epileptogenesis remains largely unknown. Recent work, however, suggests an aberrant incorporation of newborn cells into the existing hippocampal network in such a way that they promote hippocampal hyperexcitability. in the present review, we discuss current knowledge about the possible role of seizure-induced newly generated neurons and the putative involvement of ligand-gated ion channels in the process of epileptogenesis.|
|Notes: ||[Swijsen, Ann; Rigo, Jean-Michel] Hasselt Univ, BIOMED Res Inst, B-3590 Diepenbeek, Belgium. [Swijsen, Ann; Rigo, Jean-Michel] Transnatl Univ Limburg, B-3590 Diepenbeek, Belgium. [Hoogland, Govert] Univ Med Ctr Maastricht, Dept Neurosurg, Maastricht, Netherlands. [Hoogland, Govert] Univ Med Ctr Maastricht, Sch Mental Hlth & Neurosci, Maastricht, Netherlands.
|ISI #: ||000272646000052|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2010|
|Appears in Collections: ||Research publications|
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