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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10274

Title: Potential role for ligand-gated ion channels after seizure-induced neurogenesis
Authors: SWIJSEN, Ann
Hoogland, Govert
RIGO, Jean-Michel
Issue Date: 2009
Publisher: PORTLAND PRESS LTD
Citation: BIOCHEMICAL SOCIETY TRANSACTIONS, 37. p. 1419-1422
Abstract: Epileptic seizures result in an increased generation of new neurons in the dentate gyrus of the adult mammalian hippocampus. The role of these seizure-induced newborn neurons in the process of epileptogenesis remains largely unknown. Recent work, however, suggests an aberrant incorporation of newborn cells into the existing hippocampal network in such a way that they promote hippocampal hyperexcitability. in the present review, we discuss current knowledge about the possible role of seizure-induced newly generated neurons and the putative involvement of ligand-gated ion channels in the process of epileptogenesis.
Notes: [Swijsen, Ann; Rigo, Jean-Michel] Hasselt Univ, BIOMED Res Inst, B-3590 Diepenbeek, Belgium. [Swijsen, Ann; Rigo, Jean-Michel] Transnatl Univ Limburg, B-3590 Diepenbeek, Belgium. [Hoogland, Govert] Univ Med Ctr Maastricht, Dept Neurosurg, Maastricht, Netherlands. [Hoogland, Govert] Univ Med Ctr Maastricht, Sch Mental Hlth & Neurosci, Maastricht, Netherlands. jeanmichel.rigo@uhasselt.be
URI: http://hdl.handle.net/1942/10274
DOI: 10.1042/BST0371419
ISI #: 000272646000052
ISSN: 0300-5127
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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