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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/10191

Title: Mesenchymal stem cells derived from umbilical cord tissue: a therapeutic option for multiple sclerosis?
Authors: DONDERS, Raf
Advisors: MOREELS, M.
Issue Date: 2009
Publisher: tUL Diepenbeek
Abstract: Background: Multiple sclerosis is a chronic neurodegenerative disease of the central nervous system characterized by ongoing inflammation, demyelination, neuroaxonal damage and glial scar formation. Current immunomodulatory therapeutics limit inflammation but are not able to affect the underlying causes. A potential new therapeutic approach is stem cell transplantation. Animal studies have shown that mesenchymal stem cells (MSC) exert both immunomodulatory and neuroprotective functions in experimental autoimmune encephalomyelitis (EAE), the animal model of MS. The present study aims to investigate the use of MSC derived from umbilical cord tissue (UCMS). The human umbilical cord provides an easy accessible source of cells with potential for tissue repair. In order to test the potential of UCMS for cellular transplantation in MS, their potential to form neural cell types and their immunological properties will be investigated. Conclusion: The results of the present study indicate t
Notes: 2de masterjaar in de biomedische wetenschappen - klinische moleculaire wetenschappen
URI: http://hdl.handle.net/1942/10191
Category: T2
Type: Theses and Dissertations
Appears in Collections: Master theses
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